Results 51 to 60 of about 11,970 (271)
Epilepsia, EarlyView.Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva +29 more
wiley +1 more source
Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys
Equine Veterinary Journal, EarlyView.Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé +5 more
wiley +1 more source
cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies. [PDF]
PLoS ONE, 2018 The objective of this study was to translate reaction conditions and quality control methods used for production of an astatine-211(211At)-labeled anti-CD45 monoclonal antibody (MAb) conjugate, 211At-BC8-B10, from the laboratory setting to cGMP ...
Yawen Li +15 more
doaj +1 more source
International Validation of Novel Pyrogen Tests Based on Human Monocytoid Cells
, 2005 It is a requirement that parenteral medicines be tested for pyrogens (fever causing agents) using one of two animal-based tests: the rabbit pyrogen test and the bacterial endotoxin test.
BOWE Gerard +27 more
core +1 more source
Head &Neck, EarlyView.ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell +11 more
wiley +1 more source
The effect of pyrogen on the in vivo metabolism and initial kinetics of chloroquine in rats
, 1979 The possible contribution of hepatic metabolism impairment, caused by pyrogen, to the increased toxicity and altered pharmacokinetics of chloroquine in rats was investigated. The ratio of unchanged chloroquine (CQ) to total quinolines (TQ) was determined
Nosakhare G Osifo
core +1 more source
Diagnostic Performance of Ultrasound in Adult Appendicitis. A Retrospective Review of 331 Cases
Journal of Medical Radiation Sciences, EarlyView.The sensitivity of ultrasound in the detection of appendicitis had a prevalence of 16% in our predominantly young female cohort, with alternative gynaecological and abdominal diagnoses identified approximately 2:1. The sensitivity for ultrasound to detect appendicitis was 60%, with specificity of 98% and negative predictive value (NPV) of 93%.
Alistair Lock, Martin Necas
wiley +1 more source
In vivo pyrogenicity evaluation of fungal bioproducts with prebiotic potential
Revista Información Científica, 2022 Introduction: natural products with pharmacological activity require preclinical evaluations to justify their uses scientifically. The pyrogen assay is a safety pharmacology test performed to determine the presence of endotoxins and it is a valuable ...
Yamila Lebeque-Pérez +4 more
doaj
Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits
, 1985 We have compared the characteristics of fevers produced by endogenous pyrogen administered by the intravenous (iv) and by the intracerebroventricular (icv) routes in conscious rabbits.
H. A. Bernheim, J. T. Stitt
core +1 more source