Results 11 to 20 of about 3,409 (207)
Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism [PDF]
Nature Communications, 2016 In some parasites, membrane-bound pyrophosphatases, which couple proton and sodium ion transport across the membrane, are important for infectivity. Here, the authors report crystal structures of these proteins alongside biophysical analyses that allow ...
Kun-Mou Li +7 more
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Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation [PDF]
Structural Dynamics, 2017 Membrane-integral pyrophosphatases (mPPases) couple the hydrolysis of pyrophosphate (PPi) to the pumping of Na+, H+, or both these ions across a membrane.
Nita R. Shah +7 more
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The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule [PDF]
Frontiers in Molecular Biosciences, 2019 Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H+ or Na+ across membranes in a process that can be K+ dependent or independent.
Alexandra O. M. Holmes +3 more
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Understanding the Catalytic Cycle of Membrane Pyrophosphatases Through Structural and Functional Studies [PDF]
, 2017 Membrane pyrophosphatases (M-PPases) couple pyrophosphate hydrolysis to the translocation of sodium ions/protons, using the resulting ion gradients to drive abiotic stress resistance and in the infectivity of protozoan parasites.
Wilkinson, Craig
core +4 more sources
Frontiers in Microbiology, 2023 The housecleaning enzyme of Mycobacterium tuberculosis (Mtb), MazG, is a nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) and can hydrolyze all canonical or non-canonical NTPs into NMPs and pyrophosphate.
Sen Wang +9 more
doaj +1 more source
The Role of the C-terminus in Bacillus subtilis inorganic pyrophosphatase activity [PDF]
, 2003 Inorganic pyrophosphatases hydrolyse inorganic pyrophosphate ensuring that the pool of phosphate is continuously available in a cell for subsequent metabolic reactions.
Konopka, Monika
core +7 more sources
Plant Direct, 2021 Proton‐pumping pyrophosphatases (H+‐PPases) have been shown to enhance biomass and yield. However, to date, there has been little work towards identify genes encoding H+‐PPases in bread wheat (Triticum aestivum) (TaVPs) and limited knowledge on how the ...
Daniel Jamie Menadue +5 more
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Ionic Liquids as Protein Crystallization Additives
Crystals, 2021 Among its attributes, the mythical philosopher’s stone is supposedly capable of turning base metals to gold or silver. In an analogous fashion, we are finding that protein crystallization optimization using ionic liquids (ILs) often results in the ...
Crissy L. Tarver +2 more
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Na+-translocating Membrane Pyrophosphatases Are Widespread in the Microbial World and Evolutionarily Precede H+-translocating Pyrophosphatases [PDF]
, 2022 Membrane pyrophosphatases (PPases), divided into K+-dependent and K+-independent subfamilies, were believed to pump H+ across cell membranes until a recent demonstration that some K+-dependent PPases function as Na+ pumps.
Lahti R +4 more
core +1 more source
mBio, 2023 Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez +4 more
doaj +1 more source