Results 21 to 30 of about 3,409 (207)

Maf/ham1-like pyrophosphatases of non-canonical nucleotides are host-specific partners of viral RNA-dependent RNA polymerases.

PLoS Pathogens, 2022
Cassava brown streak disease (CBSD), dubbed the "Ebola of plants", is a serious threat to food security in Africa caused by two viruses of the family Potyviridae: cassava brown streak virus (CBSV) and Ugandan (U)CBSV.
Adrian A Valli, Rafael García López, María Ribaya, Francisco Javier Martínez, Diego García Gómez, Beatriz García, Irene Gonzalo, Alfonso Gonzalez de Prádena, Fabio Pasin, Inmaculada Montanuy, Encarnación Rodríguez-Gonzalo, Juan Antonio García   +11 more
doaj   +1 more source

The inorganic pyrophosphatases of microorganisms: a structural and functional review [PDF]

PeerJ
Pyrophosphatases (PPases) are enzymes that catalyze the hydrolysis of pyrophosphate (PPi), a byproduct of the synthesis and degradation of diverse biomolecules. The accumulation of PPi in the cell can result in cell death.
Rodolfo García-Contreras, Javier de la Mora, Héctor Manuel Mora-Montes, José A. Martínez-Álvarez, Marcos Vicente-Gómez, Felipe Padilla-Vaca, Naurú Idalia Vargas-Maya, Bernardo Franco   +7 more
doaj   +2 more sources

PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

Frontiers in Oncology, 2022
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo sapiens, as well as significantly in a variety of malignancies.
Shuying Wang, Shuying Wang, Jianmei Wei, Shunwei Li, Yuyin Luo, Yuyin Luo, Yifei Li, Xianglin Wang, Xianglin Wang, Wenzhi Shen, Dehong Luo, Daishun Liu   +11 more
doaj   +1 more source

mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations.

PLoS Computational Biology, 2022
Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across the membrane.
Alexandra O M Holmes, Adrian Goldman, Antreas C Kalli   +2 more
doaj   +1 more source

RETRACTED: Pyrophosphate modulates plant stress responses via SUMOylation

eLife, 2019
Pyrophosphate (PPi), a byproduct of macromolecule biosynthesis is maintained at low levels by soluble inorganic pyrophosphatases (sPPase) found in all eukaryotes. In plants, H+-pumping pyrophosphatases (H+-PPase) convert the substantial energy present in
M Görkem Patir-Nebioglu, Zaida Andrés, Melanie Krebs, Fabian Fink, Katarzyna Drzewicka, Nicolas Stankovic-Valentin, Shoji Segami, Sebastian Schuck, Michael Büttner, Rüdiger Hell, Masayoshi Maeshima, Frauke Melchior, Karin Schumacher   +12 more
doaj   +1 more source

Chick Aorta Pyrophosphatase

Experimental Biology and Medicine, 1973
SummaryChick aorta inorganic pyrophosphatase is inhibited by collagen and micromolar amounts of calcium.
M, Chen, J, McCarry, M M, Chan, R S, Riggins, R B, Rucker   +4 more
openaire   +2 more sources

The exopolyphosphatase TbrPPX1 of Trypanosoma brucei

BMC Microbiology, 2011
Background Exopolyphosphatases and pyrophosphatases play important but still incompletely understood roles in energy metabolism, and also in other aspects of cell biology such as osmoregulation or signal transduction.
Freimoser Florian, Wentzinger Laurent, Kunz Stefan, Luginbuehl Edith, Seebeck Thomas   +4 more
doaj   +1 more source

Additional file 5 of Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors

, 2023
Additional file 5: Figure S5.
Rubayet Elahi (4573318), Anders Wallqvist (43485), Shivendra G. Tewari (8452482), Bobby Kwan (15262237), Sean T. Prigge (370088), Krithika Rajaram (3350864), Akhil B. Vaidya (245862), Suyash Bhatnagar (15262240), Jaques Reifman (43486)   +8 more
core   +1 more source

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

Scientific Reports, 2022
Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage.
Antonio E. Vidal, Miriam Yagüe-Capilla, Blanca Martínez-Arribas, Daniel García-Caballero, Luis M. Ruiz-Pérez, Dolores González-Pacanowska   +5 more
doaj   +1 more source

Lack of Vacuolar H+ -Pyrophosphatase and Cytosolic Pyrophosphatases Causes Fatal Developmental Defects in Arabidopsis thaliana

Frontiers in Plant Science, 2020
The cytosolic level of inorganic pyrophosphate (PPi) is finely regulated, with PPi hydrolyzed primarily by the vacuolar H+-pyrophosphatase (H+-PPase, VHP1/FUGU5/AVP1) and secondarily by five cytosolic soluble pyrophosphatases (sPPases; PPa1–PPa5) in ...
Mayu Fukuda, Marika Mieda, Ryosuke Sato, Satoru Kinoshita, Takaaki Tomoyama, Ali Ferjani, Masayoshi Maeshima, Masayoshi Maeshima, Shoji Segami, Shoji Segami   +9 more
doaj   +1 more source