Results 31 to 40 of about 3,409 (207)
Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2018 The flavin cofactors FMN and FAD are required for a wide variety of biological processes, however, little is known about their metabolism. Here, we report the cloning and biochemical characterization of the Saccharomyces cerevisiae pyrophosphatase Fpy1p.
Joseph H Lynch +4 more
doaj +1 more source
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation
Angewandte Chemie, EarlyView.YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue +2 more
wiley +2 more sources
Genomics-guided analysis of NAD recycling yields functional elucidation of COG1058 as a new family of pyrophosphatases. [PDF]
PLoS ONE, 2013 We have recently identified the enzyme NMN deamidase (PncC), which plays a key role in the regeneration of NAD in bacteria by recycling back to the coenzyme the pyridine by-products of its non redox consumption.
Lucia Cialabrini +7 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2019 A two-step palladium-catalyzed procedure based on Suzuki–Miyaura cross coupling, followed by a double Buchwald–Hartwig reaction, allows for the synthesis of pharmaceutically relevant benzo[4,5]furo[3,2-b]indoles in moderate to very good yield.
Hoang Huy Do +7 more
doaj +1 more source
Biointerference relationship between the macroalga Ulva lactuca and two green microalgae
Egyptian Journal of Aquatic Research, 2021 Allelopathy is considered as a physiological phenomenon with ecological implications that have stimulatory or inhibitory effects on organisms. The aim of the present study was focused on the effect of Ulva lactuca aqueous extract on growth and some ...
Salama M. El-Darier +3 more
doaj +1 more source
Structural and Biochemical Characterization of Apicomplexan Inorganic Pyrophosphatases
Scientific Reports, 2017 Inorganic pyrophosphatases (PPase) participate in energy cycling and they are essential for growth and survival of organisms. Here we report extensive structural and functional characterization of soluble PPases from the human parasites Plasmodium ...
Abhishek Jamwal +4 more
doaj +1 more source
Identification and analysis of proton-translocating pyrophosphatases in the methanogenic archaeon Methanosarcina mazei [PDF]
, 2002 Analysis of genome sequence data from the methanogenic archaeon Methanosarcina mazei Gö1 revealed the existence of two open reading frames encoding proton-translocating pyrophosphatases (PPases).
Lentes, Sabine +3 more
core +1 more source
Scientific Reports, 2021 Proton-translocating inorganic pyrophosphatases (H+-PPases) are an ancient family of membrane bound enzymes that couple pyrophosphate (PPi) hydrolysis to H+ translocation across membranes.
I. Folgueira +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 The possible evolutionary significance of pyrophosphate (PPi) has been discussed since the early 1960s. Lipmann suggested that PPi could have been an ancient currency or a possible environmental source of metabolic energy at origins, while Kornberg ...
Jessica L. E. Wimmer +2 more
doaj +1 more source
Integral membrane pyrophosphatases: a novel drug target for human pathogens? [PDF]
, 2016 Membrane-integral pyrophosphatases (mPPases) are found in several human pathogens, including Plasmodium species, the protozoan parasites that cause malaria.
Goldman, A +7 more
core +1 more source