Results 31 to 40 of about 82,695 (167)

Thermodynamic examination of the pyrophosphate sensor helix in the thiamine pyrophosphate riboswitch [PDF]

RNA, 2011
Riboswitches are functional mRNA that control gene expression. Thiamine pyrophosphate (TPP) binds tothi-box riboswitch RNA and allosterically inhibits genes that code for proteins involved in the biosynthesis and transport of thiamine. Thiamine binding to the pyrimidine sensor helix and pyrophosphate binding to the pyrophosphate sensor helix cause ...
Stephanie, Furniss, Neena, Grover
openaire   +2 more sources

Energetic Constraints and Carbon Efficiency During Sucrose Storage in Sugarcane Culms

Agronomy
Sugarcane stores sucrose in a living culm for extended periods, yet the respiratory cost of maintaining this storage tissue remains poorly quantified. We quantified growth and maintenance respiration along the culm (internodes 1 to 12) in three genotypes
Frederik C. Botha
doaj   +1 more source

Liver-directed base editing of ABCC6 prevents ectopic calcification in a variant-humanized mouse model of pseudoxanthoma elasticum

Molecular Therapy: Nucleic Acids
Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries.
Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang   +8 more
doaj   +1 more source

Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario

Life, 2020
The availability of nucleotides on the early Earth is of great significance for the origin of a self-replicating system capable of undergoing evolution. We hereby report the successful phosphorylation reactions of the nucleoside uridine under heating in ...
Maheen Gull, Arthur Omran, Tian Feng, Matthew A. Pasek   +3 more
doaj   +1 more source

Pyrophosphate of Iron [PDF]

The Boston Medical and Surgical Journal
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openaire   +2 more sources

Thermal and pH stability of Δ2-isopentenyl pyrophosphate

Journal of Lipid Research, 1972
The isoprenoid precursors Δ3-isopentenyl pyrophosphate and γ,γ-dimethylallyl pyrophosphate (Δ2-isopentenyl pyrophosphate) have been separated by thin-layer chromatography.
D.M. Logan
doaj   +1 more source

Alkaline Phosphatases Account for Low Plasma Levels of Inorganic Pyrophosphate in Chronic Kidney Disease

Frontiers in Cell and Developmental Biology, 2020
IntroductionPatients on dialysis and kidney transplant recipients (KTR) present the syndrome of mineral and bone disorders (MBD), which share common traits with monogenic calcifying diseases related to disturbances of the purinergic system.
Audrey Laurain, Audrey Laurain, Audrey Laurain, Isabelle Rubera, Christophe Duranton, Frank Rutsch, Yvonne Nitschke, Elodie Ray, Sandor Vido, Antoine Sicard, Antoine Sicard, Georges Lefthériotis, Georges Lefthériotis, Georges Lefthériotis, Guillaume Favre, Guillaume Favre, Guillaume Favre   +16 more
doaj   +1 more source

Mathematical Modeling of a Supramolecular Assembly for Pyrophosphate Sensing

Frontiers in Chemistry, 2021
The power of sensing molecules is often characterized in part by determining their thermodynamic/dynamic properties, in particular the binding constant of a guest to a host.
Fereshteh Emami, Hamid Abdollahi, Tsyuoshi Minami, Ben Peco, Sean Reliford   +4 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio
The predominant cause of death among diabetic patients comes from cardiovascular complications, including vascular calcification. The objectives of this study were to improve the understanding of the molecular mechanisms involved in diabetes‐related ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
doaj   +1 more source

Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments

Life, 2020
All life on Earth uses one universal biochemistry stemming from one universal common ancestor of all known living organisms. One of the most striking features of this universal biochemistry is its utter dependence on phosphate group transfer between ...
Radosław W. Piast, Maciej Garstka, Aleksandra Misicka, Rafał M. Wieczorek   +3 more
doaj   +1 more source