Results 111 to 120 of about 77,046 (386)
BMC Musculoskeletal Disorders, 2023 Purpose Steroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with glucocorticoids being the most common cause. Previous experimental studies have shown that cell pyroptosis
Jin-Lian Chai +5 more
doaj +1 more source
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Nature Immunology, 2020 Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD).
J. Hu +17 more
semanticscholar +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy
Advanced SciencePyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin +8 more
doaj +1 more source
A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread [PDF]
, 2012 The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic spread unless dissemination is blocked in the lymph node itself.
Germain, R. +4 more
core +1 more source
Advanced Functional Materials, EarlyView.A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang +8 more
wiley +1 more source
Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. [PDF]
, 2019 Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1-3 (HNP1-3) are the most abundant neutrophil granule proteins but their neutrophil content varies because ...
Chen, QiXing +12 more
core +1 more source
Advancement of science, 2023 The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing tumor recurrence and metastasis.
Xuya Yu +8 more
semanticscholar +1 more source
Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers
Advanced Healthcare Materials, EarlyView.The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao +7 more
wiley +1 more source
Gasdermins in Apoptosis: New players in an Old Game. [PDF]
, 2019 Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
core +1 more source