Results 141 to 150 of about 77,046 (386)

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Journal of Hematology & Oncology, 2020
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to ...
Ronghua Tang, Jin Xu, Bo Zhang, Jiang Liu, C. Liang, J. Hua, Qingcai Meng, Xianjun Yu, S. Shi   +8 more
semanticscholar   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Emerging concepts about NAIP/NLIRC4 inflammasomes [PDF]

, 2014
Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol ...
Aits, Akhter, Amer, Barry, Bastos, Bellora, Berda-Haddad, Bergsbaken, Bergsbaken, Bergsbaken, Bonaldi, Bortoluci, Brennan, Brodsky, Broz, Broz, Buzzo, Byrne, Carta, Casciola-Rosen, Chen, Chen, Chung, Cookson, Delaleu, Diez, Dinarello, Dinarello, Dinarello, Dinarello, Dinarello, Dinarello, Erener, Evankovich, Faustin, Fettelschoss, Fink, Fortier, Franchi, Franchi, Franchi, Gabay, Garaude, Geddes, Gross, Halff, Hassa, Hayashi, Howard, Hu, Hu, Hu, Janowski, Jounai, Kanneganti, Kayagaki, Keller, Kim, Kofoed, Kofoed, Kolb, Kraus, Krishnakumar, Kuida, Kupz, Lage, Lage, Lamkanfi, Lamkanfi, Lasigliè, Li, Lightfield, Lightfield, Lopez-Yglesias, Lu, Lundberg, Malireddi, Man, Mariathasan, Martinon, Martinon, Maslanik, McCoy, Miao, Miao, Miao, Molofsky, Mosley, Muller, Nakanishi, Nicholson, Nosseri, Nyström, Poyet, Puren, Qu, Rayamajhi, Ren, Sanders, Sanders, Schroder, Siegmund, Silveira, Sims, Sutterwala, Sutterwala, Suzuki, Tenthorey, Ting, Tomalka, Van der Meer, Vijay-Kumar, von Moltke, von Moltke, Yang, Zamboni, Zhao, Zheng   +117 more
core   +2 more sources

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source

Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection [PDF]

, 2015
SummaryProgression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissues.
Doitsh, Gilad, Greene, Warner C., Muñoz-Arias, Isa, Ruelas, Debbie, Sowinski, Stefanie, Yang, Zhiyuan   +5 more
core   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Transcriptomic analyses reveal differential gene expression of immune and cell death pathways in the brains of mice infected with West Nile virus and chikungunya virus [PDF]

, 2017
West Nile virus (WNV) and chikungunya virus (CHIKV) are arboviruses that are constantly (re-)emerging and expanding their territory. Both viruses often cause a mild form of disease, but severe forms of the disease can consist of neurological symptoms ...
Andeweg, A.C. (Arno), Ham, H.J. van den, IJcken, W.F.J. (Wilfred) van, Koraka, P. (Penelope), Lim, S.M. (Stephanie), Martina, B.E.E. (Byron), Martina, E. (Eurydice), Oduber, M. (Minoushka), Osterhaus, A.D.M.E. (Albert), Roose, J.M. (Jeroen M.), Zaaraoui-Boutahar, F. (Fatiha)   +10 more
core   +2 more sources

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer

Journal for ImmunoTherapy of Cancer
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy.
Tao Zhang, Jing Zhang, Lei Zhao, Jinghua Ren, Zhenyu Lin, Pengfei Zhou, Dejun Zhang, Dandan Yu, Lisha Li, Diwei Zhou, Yuanhang Yu, Peiyi Zhang, Jinge Zheng   +12 more
doaj   +1 more source