Results 241 to 250 of about 82,547 (381)

The role of pyroptosis in ovarian cancer. [PDF]

Discov Oncol
Zhou Y, Peng T, Zhang J, Liang R.
europepmc   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

Corynebacterium pseudotuberculosis phospholipase D targets mitochondrial sphingomyelin and induces NLRP3-GSDMD axis-mediated pyroptosis in macrophages to promote infection. [PDF]

Vet Res
Li X, Lv H, Wu C, Li H, Yi W, Niu X, Peng Q, Meng C, Yuan Y, Tian S, Wang Z, Fang R, Zhou Z.   +12 more
europepmc   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

AXL activation governs the liver microenvironment to protect ischemia-reperfusion injury by suppressing NLRP3 inflammasome. [PDF]

Cell Mol Biol Lett
Liu D, Zhan M, Yao L, Liu X, Zhang R, Zha L, Zhang X, Xu Y, Fang Q, Cai H, Yan Q, Wang W, Du J, Chen L.   +13 more
europepmc   +1 more source

Progress of pyroptosis in acute pancreatitis

Chinese Medical Journal, 2021
Hong-Yao Li, Yu-Jie Lin, Ling Zhang, Jing Zhao, Dan-Yang Xiao, Zhen-Zhen Huang, Pei-Wu Li, Yuan-Yuan Ji   +7 more
openaire   +4 more sources

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Benzene metabolites trigger pyroptosis and contribute to haematotoxicity via TET2 directly regulating the Aim2/Casp1 pathway [PDF]

, 2019
Xiaoli Guo, Wen Zhong, Yujiao Chen, Wei Zhang, Jing Ren, Ai Gao   +5 more
openalex   +1 more source

Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. [PDF]

Mol Med Rep
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S, Fei B.   +7 more
europepmc   +1 more source

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

Medicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source