Results 251 to 260 of about 59,289 (299)

Feiwei Heji Enhances Antitumor Immunity by MLL4-Dependent Regulation of Pyroptosis in Lung Cancer. [PDF]

Cancer Sci
Cheng N, Jiang R, Li W, Huang W, Peng Q, Zhao T, Zhang C.   +6 more
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy. [PDF]

J Extracell Vesicles
Dou G, Liu J, Tian R, Zhang K, Suo M, Zhou D, Zhang Y, Liu X, Qiu X, Kuang J, Zou Z, Wang S, Zhao L, Ding F, Wang D, Guan C, Zhu X, Wang D, Liu S, Zhang T, Zhao Y, Liu S.   +21 more
europepmc   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications. [PDF]

MedComm (2020)
Boaru DL, De Castro-Martinez P, Garcia-Montero C, Fraile-Martinez O, Alhaddadin MNM, Barrena-Blázquez S, Lopez-Gonzalez L, Fernández CT, Alvarado-Hurtado R, Giménez TR, Lasa-Unzúe I, Alonso MD, Gutiérrez-Calvo A, Saez MA, Cobo-Prieto D, Saz JV, Alvarez-Mon M, Diaz-Pedrero R, Ortega MA.   +18 more
europepmc   +1 more source

EXPRESSION OF CONCERN: KLF4 Interacts With TXNIP to Modulate the Pyroptosis in Ulcerative Colitis via Regulating NLRP3 Signaling. [PDF]

Immun Inflamm Dis
europepmc   +1 more source

Tuoli Tounong decoction promotes lesion resolution in granulomatous lobular mastitis by remodeling a Caspase-8-associated PANoptosis-like cell death network. [PDF]

Front Immunol
Yuan Y, Zuo X, Gao X, Wang Y, Li X, Li Q, Chen Z, Shi X.   +7 more
europepmc   +1 more source

ROS-Dependent GSDMD Activation Drives Intestinal Pyroptosis in Neonatal Necrotizing Enterocolitis (NEC). [PDF]

Cell Biol Int
Ye C, Luo J, Liu X, Ma Y, Yang X, Mo D, Deng Q, Ding X, Guo C.   +8 more
europepmc   +1 more source

Let-7a-5p/SHIP-1 Axis Drives SARS-CoV-2 Spike-1-Induced Microglial Pyroptosis. [PDF]

Int J Mol Sci
Pawar P, Ratnakar S, Saxena V.
europepmc   +1 more source

Gasdermin D in pyroptosis

Acta Pharmaceutica Sinica B, 2021
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Hua Zhu, Brandon Burdette, Shanzhi Wang   +2 more
exaly   +4 more sources

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Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources