Results 261 to 270 of about 53,711 (308)

Galangin alleviates cold stress-induced splenic injury in Danzhou chickens by inhibiting NLRP3 inflammasome-mediated pyroptosis. [PDF]

Poult Sci
Tian X, Dai C, Fan W, Cheng C, Lu W, Peng H, Yang D.   +6 more
europepmc   +1 more source

A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor. [PDF]

Mater Today Bio
Yang C, Wang X, Zhu M, Shi S, Zhu S, Gu Z, Du J.   +6 more
europepmc   +1 more source

The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway. [PDF]

FASEB J
Zhu Y, Cai X, Zheng Q, Fang C, Pan Z, Wang Y.   +5 more
europepmc   +1 more source

Gasdermin family: a promising therapeutic target for asthma. [PDF]

Front Med (Lausanne)
Wang C, Zhang X, Cheng F, Huang H, Li X.
europepmc   +1 more source

Identification of pyroptosis and hypoxia related molecular subtypes and a prognostic signature in colorectal cancer. [PDF]

Discov Oncol
Wang H, Chen Y.
europepmc   +1 more source

Integrated single-cell and bulk RNA sequencing analysis identifies a pyroptosis related prognostic model for predicting prognosis and therapeutic response in intrahepatic cholangiocarcinoma. [PDF]

Discov Oncol
Ma P, Hu T, Long X, Zhang S, Liu F, Wang H, Wu H.   +6 more
europepmc   +1 more source

Gasdermin D in pyroptosis

Acta Pharmaceutica Sinica B, 2021
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E Burdette, Ashley N Esparza, Hua Zhu   +2 more
exaly   +4 more sources

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Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources

Gasdermins: Effectors of Pyroptosis [PDF]

Trends in Cell Biology, 2017
Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Edward A Miao
exaly   +3 more sources