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Gasdermin D in pyroptosis

Acta Pharmaceutica Sinica B, 2021
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E Burdette, Ashley N Esparza, Hua Zhu   +2 more
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Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources

Gasdermins: Effectors of Pyroptosis [PDF]

Trends in Cell Biology, 2017
Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Edward A Miao
exaly   +3 more sources

Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Abdullah, Al Mamun, Anjuman, Ara Mimi, Yanqing, Wu, Muhammad, Zaeem, Md, Abdul Aziz, Suzia, Aktar Suchi, Eman, Alyafeai, Fahad, Munir, Jian, Xiao   +8 more
openaire   +2 more sources

Coral gasdermin triggers pyroptosis

Science Immunology, 2020
Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang, Zhi Zhou, Yuanyuan Sun, Tengfei Zhang, Li Sun   +4 more
openaire   +2 more sources

Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
openaire   +2 more sources

Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy

Journal of the American Chemical Society, 2023
Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self-protective mechanism of cancer cells significantly weakens the therapeutic efficiency. Here, a bioorthogonal pyroptosis nanoregulator is constructed to induce pyroptosis and disrupt
Wenting Zhang, Zhengwei Liu, Jiawei Zhu, Zhenqi Liu, Yu Zhang, Geng Qin, Jinsong Ren, Xiaogang Qu   +7 more
openaire   +2 more sources

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
openaire   +2 more sources

Pyroptosis heats tumour immunity

Nature Reviews Immunology, 2020
Two studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.
openaire   +2 more sources

Epithelial Pyroptosis in Host Defense

Journal of Molecular Biology, 2022
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases including the proinflammatory caspases downstream of inflammasome activation.
Madeline J. Churchill, Patrick S. Mitchell, Isabella Rauch   +2 more
openaire   +2 more sources