Results 271 to 280 of about 53,711 (308)

Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Abdullah, Al Mamun, Anjuman, Ara Mimi, Yanqing, Wu, Muhammad, Zaeem, Md, Abdul Aziz, Suzia, Aktar Suchi, Eman, Alyafeai, Fahad, Munir, Jian, Xiao   +8 more
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Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
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Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
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PYROPTOSIS and THE MECHANISM OF PYROPTOSIS

2023
Hücresel inflamatuar nekrozolarak da bilinen piroptoz, programlanmış hücre ölümünün yeni bir şeklidir. İlkolarak 1992'de Gram negatif bakterilerle enfekte olmuş makrofajlarda tanımlananpiroptozis daha sonra çeşitli bağışıklık hücrelerinde de bildirilmiştir.
Gezer, Arzu, Karadağ Sarı, Ebru
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Ferroptosis and Pyroptosis in Epilepsy

Molecular Neurobiology
Epilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and pyroptosis are newly discovered ways of programmed cell death. One of the characteristics of ferroptosis is the oxidative stress generated by lipid peroxides.
Fan Feng, Rong Luo, Dezhi Mu, Qianyun Cai   +3 more
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Role of pyroptosis in liver diseases

International Immunopharmacology, 2020
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines.
Abdullah, Al Mamun, Yanqing, Wu, Chang, Jia, Fahad, Munir, Kasfia Jahan, Sathy, Tamanna, Sarker, Ilma, Monalisa, Kailiang, Zhou, Jian, Xiao   +8 more
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Role of gasotransmitters in pyroptosis

International Journal of Biological Macromolecules
Pyroptosis is a special form of programmed cell death. Pyroptosis is triggered by inflammasomes. The main morphological change is that the cells continue to expand until the cell membrane ruptures, and then the cell contents are released, triggering a strong inflammatory response.
Hong-Jie, Li, Meng-Yuan, Hao, Hang-Shen, Han, Ti, Chu, Yan-Wen, Wang, Wei-Rong, Si, Qi-Ying, Jiang, Dong-Dong, Wu   +7 more
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A checkpoint for pyroptosis

Science Signaling, 2020
The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
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Inflammasome-independent pyroptosis

Current Opinion in Immunology
Gasdermins are membrane pore-forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans - gasdermins A to E.
Xing, Liu, Judy, Lieberman
openaire   +2 more sources