Results 291 to 300 of about 82,547 (381)

Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

, 2020
Jiezhou Ye, Bo Zeng, Mei-Yan Zhong, Hongchun Li, Lihui Xu, Jun-Xiang Shu, Yaofeng Wang, Fan Yang, Chun-Su Zhong, Xun-jia Ye, Xian‐Hui He, Dong‐Yun Ouyang   +11 more
openalex   +1 more source

Pyroptosis-Related Molecular Clusters and Immune Infiltration in Pediatric Sepsis. [PDF]

Pediatric Health Med Ther
Lin M, Li C, Wang Y, Liu J, Ye H.
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

, 2019
Nirmal Robinson, Raja Ganesan, Csaba Hegedűs, Katalin Kovács, Thomas A. Kufer, László Virág   +5 more
openalex   +1 more source

Zerumbone Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the NLRP3/Caspase-1/GSDMD Signalling Pathway. [PDF]

J Cell Mol Med
Xu YJ, Fang FF, Zhao GQ, Yu WY, Han HY, Teng H, Lyu JN, Wang JF.   +7 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3. [PDF]

J Inflamm Res
Liang Y, Gan Q, Zhong X, Lan T, Yang Y, Lin L, Tang C, Liang H.   +7 more
europepmc   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Homocysteine-Mediated Neuronal Pyroptosis Contributes to Brain Injury in Heatstroke Rats by Activating the m⁶A-YTHDF2-NLRP3 Pathway. [PDF]

Cells
Zhang S, Xie F, Wang X, Sun Z, Zhang L, Liu W, Chen X, Qian L, Zhao Y.   +8 more
europepmc   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, EarlyView.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source