Results 71 to 80 of about 63,272 (185)

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

Cell Death Discovery, 2022
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
Siyu Wang, Hua Wang, Chengyao Feng, Chenbei Li, Zhihong Li, Jieyu He, Chao Tu   +6 more
doaj   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

Pyroptosis Takes Aim at Neurodevelopment [PDF]

Developmental Cell, 2020
In a recent issue of Nature, Lammert et al. demonstrate that DNA damage drives AIM2-mediated pyroptosis during normal brain development, preventing anxiety-like behaviors acquisition in adults and revealing an important role for non-apoptotic mechanisms of cell death during neurodevelopment.
Jaeda C, Coutinho-Budd, Heather T, Broihier   +1 more
openaire   +2 more sources

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture [PDF]

, 2019
Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1 beta and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11
Lamkanfi, Mohamed, Moraes de Vasconcelos, Nathalia, Parthoens, Eef, Van Gorp, Hanne, Van Opdenbosch, Nina   +4 more
core   +1 more source

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy

Advanced Science
Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin, Tanzhou Chen, Xiaoqu Hu, Wenting Zhu, Yida Li, Wenjie Sun, Lei Li, Hongmei Zhang, Qinyang Wang   +8 more
doaj   +1 more source

Inhibition of caspase-1 prolongs survival of mice infected with rabies virus [PDF]

, 2018
Rabies virus infects almost all mammals resulting in lethal disease. To date there is no treatment available for symptomatic rabies and there is an urgent need to develop treatment strategies that would prolong survival, thereby providing a window of ...
Baumgärtner, V. (Volkmar), Begeman, L. (Lineke), D.M.E. Osterhaus, A. (Albert), Gerhauser, I. (Ingo), Koraka, P. (Penelope), Martina, B.E.E. (Byron), Marzec, A. (Anna), Orlowska, A. (Anna), Roose, J.M. (Jouke M.), Smreczak, M. (Marcin), Trebas, P. (Pawel), Wohlsein, P. (Peter), Zmudzinski, J. (Jan)   +12 more
core   +2 more sources

Pyroptosis in spinal cord injury

Frontiers in Cellular Neuroscience, 2022
Spinal cord injury (SCI) often brings devastating consequences to patients and their families. Pathophysiologically, the primary insult causes irreversible damage to neurons and glial cells and initiates the secondary damage cascade, further leading to inflammation, ischemia, and cells death.
Jian Yin, Jian Yin, Ge Gong, Wenhui Wan, Xinhui Liu   +4 more
openaire   +3 more sources

Bridging Pyroptosis and Immunity: A Comprehensive Study of the Pyroptosis-Related Long Non-Coding RNA Signature in Breast Cancer

Life, 2023
Breast cancer continuously poses serious clinical challenges to human health due to its intrinsic heterogenicity and evolving drug resistance. Recently, increasing evidence has shown that pyroptosis, known as a programmed and inflammatory form of cell ...
Ye Tian, Jing Dong, Lin Li
doaj   +1 more source

Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages

Cell Communication and Signaling, 2020
Background Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells.
Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li, Zhigang Wang   +10 more
doaj   +1 more source

Relationship of EGFR-TKI Targeted Therapy and Pyroptosis in Non-small Cell Lung Cancer

Zhongliu Fangzhi Yanjiu, 2023
Objective To explore the relationship between pyroptosis and treatment in non-small cell lung cancer patients treated with tyrosine kinase inhibitors targeted therapy.
CHEN Jiachen, WU Tingyu, XIA Weiliang
doaj   +1 more source