Results 71 to 80 of about 42,330 (202)

Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination

Journal of Neuroinflammation, 2023
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed in CNS diseases recently.
Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, Minjie Xie   +10 more
doaj   +1 more source

ROS induced pyroptosis in inflammatory disease and cancer

Frontiers in Immunology
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various
Jingsong Wang, Ziyong Wu, Min Zhu, Yang Zhao, Jingwen Xie, Jingwen Xie   +5 more
doaj   +1 more source

Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury

Journal of Neuroinflammation, 2020
Background Spinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage.
Xuefei Li, Zhiyuan Yu, Weifeng Zong, Peng Chen, Jia Li, Minghuan Wang, Fengfei Ding, Minjie Xie, Wei Wang, Xiang Luo   +9 more
doaj   +1 more source

Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer

Journal for ImmunoTherapy of Cancer
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy.
Tao Zhang, Jing Zhang, Lei Zhao, Jinghua Ren, Zhenyu Lin, Pengfei Zhou, Dejun Zhang, Dandan Yu, Lisha Li, Diwei Zhou, Yuanhang Yu, Peiyi Zhang, Jinge Zheng   +12 more
doaj   +1 more source

GAS5-inhibited hepatocyte pyroptosis contributes to hepatic stellate cell inactivation via microRNA-684 and AHR

iScience, 2023
Summary: Hepatocyte pyroptosis has been shown to be involved in liver damage progression. Previously, we found that growth arrest-specific 5 (GAS5) is a regulator of hepatic stellate cell (HSC) activation. However, whether GAS5 plays a role in hepatocyte
Zhichao Lang, Rongrong Zhang, Xinmiao Li, Yan Jin, Yuhang Hu, Xinyi Lin, Yunzhi Tang, Jingnan Zhang, Lei Zheng, Zhixian Yu, Jianjian Zheng   +10 more
doaj  

Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis

Advanced Science
Embryo implantation and decidualization are crucial for a successful pregnancy. How the inflammatory response is regulated during these processes is undefined. Pyroptosis is an inflammatory form of cell death mediated by gasdermin D (GSDMD).
Meng‐Yuan Li, Ying Wu, Hao‐Lan Tang, Ying Wang, Bo Li, Yu‐Ying He, Gui‐Jun Yan, Zeng‐Ming Yang   +7 more
doaj   +1 more source

Induction of Pyroptosis and Its Implications in Cancer Management

Frontiers in Oncology, 2019
Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral ...
Yan-Yang Wang, Yan-Yang Wang, Xin-Lan Liu, Ren Zhao, Ren Zhao   +4 more
doaj   +1 more source

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles [PDF]

, 2011
Anna C. Reisetter, Larissa V. Stebounova, Jonas Baltrušaitis, Linda S. Powers, Amit Gupta, Vicki H. Grassian, Martha M. Monick   +6 more
openalex   +1 more source

Immunogenic cell death triggered by pathogen ligands via host germ line-encoded receptors [PDF]

arXiv
The strategic induction of cell death serves as a crucial immune defense mechanism for the eradication of pathogenic infections within host cells. Investigating the molecular mechanisms underlying immunogenic cell pathways has significantly enhanced our understanding of the host's immunity.
arxiv  

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells [PDF]

, 2012
Seth L. Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A. O’Donnell, Kate McArthur, Tracey M. Baldwin, Stéphane Chevrier, Cameron J. Nowell, Louise H. Cengia, Katya J. Henley, Janelle E. Collinge, Daniel L. Kastner, Lionel Feigenbaum, Douglas J. Hilton, Warren S. Alexander, Benjamin T. Kile, Ben A. Croker   +18 more
openalex   +1 more source