Results 161 to 170 of about 31,966 (258)

Confinement Effects in High‑Efficiency Electrocatalysis: Design, Mechanisms, and Applications

Interdisciplinary Materials, EarlyView.
Confinement has emerged as a powerful strategy in electrocatalysis and has been widely employed to enhance catalytic performance. This review summarizes recent advances in confined electrocatalysis, encompassing the design of confined electrocatalysts, mechanistic insights into confinement effects, and representative applications across diverse zero ...
Congcong Yang, Zhihang Liu, Jingshuo Liu, Chuang Chen, Zhiqun Lin, Likun Gao   +5 more
wiley   +1 more source

Discovery, Structure-Activity Relationship, and Functional Characterization of a Chromenopyrrole Series as Orthosteric Antagonists of GPR84. [PDF]

J Med Chem
Malone MA, Yin R, Li Y, Jenkins L, Guseinov AA, Marsango S, Huggett M, Huggett M, Boyle A, Morrison A, Tikhonova IG, Milligan G, Jamieson AG.   +12 more
europepmc   +1 more source

Bayesian optimization enables balanced ambipolar transport in self‐doped random conjugated polymers

InfoMat, EarlyView.
The integration of side‐chain self‐doping with Bayesian optimization enables balanced ambipolar transport in random conjugated polymers with only six experiments, establishing a general and efficient paradigm for the rational design of flexible electronic materials.
Pinyu Chen, Xiangrui Gong, Tianqiang Cui, Bolun Huang, Ying Jiang, Ye Zou, Lang Jiang, Baoxin Zhang, Chengshan Yuan, Xiangfeng Shao, Hao‐Li Zhang, Zitong Liu   +11 more
wiley   +1 more source

A Three-Step Route to Functionalized Pyrrole-2,5-Dicarboxylic Acids from Galactaric Acid. [PDF]

ChemSusChem
Trapasso G, Dalla Torre D, Artuso M, Aricò F.   +3 more
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Enantioselective Iridium-Catalyzed C-H Bond Alkylation for the Synthesis of N-N Atropisomeric Phosphines. [PDF]

J Am Chem Soc
Fu SH, Pang RJ, Yue Y, Xi LL, Feng J, Liu RR.   +5 more
europepmc   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Red blood cell damage defines the etiology of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids. [PDF]

Acta Pharm Sin B
Song Z, He Y, Zhang W, Lian W, Pan Y, Ma J, Zhao Y, Huang T, Zhuge Y, Lin G.   +9 more
europepmc   +1 more source