Results 111 to 120 of about 18,845 (239)
Open PhysicsThis work explores six newly designed compounds obtained by several substitutions in 2,5-di(2-thienyl) pyrrole molecule. For this series of compounds, the electronic and optical properties were investigated using density functional theory and time ...
Aljaafreh Mamduh J., Hussein Rageh. K.
doaj +1 more source
, 2016 Mixing readily available alkynes, pyrroles, and triethylsilane along with an indium catalyst was found to be an efficient procedure to introduce alkyl groups onto a β-position of pyrroles in a complete regioselective manner.
Tatsuya Wagatsuma (2373394) +3 more
core +1 more source
, 1996 The reaction of 1-substituted vinamidinium salts with sarcosine ethyl ester produced 2,3-disubstituted pyrroles; a similar reaction with glycine ethyl ester gave 2,5-disubstituted pyrroles.
Gupton, John T. +2 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer +6 more
wiley +1 more source
Palladium-Catalyzed Cascade Process To Construct 1,2,5-Trisubstituted Pyrroles
, 2016 A novel palladium-catalyzed cascade allylic amination/intramolecular hydroamination/isomerization process of protected enynol 1 and primary amine 2 has been explored, which constructs the important 1,2,5-trisubstituted pyrroles.
Yong-Qiang Zhang (767549) +6 more
core +1 more source
Dual‐Function Cosubstrates Enable Threonine Dehydrogenase‐Driven Chemoenzymatic Pyrrole Synthesis
Angewandte Chemie International Edition, EarlyView.Classical Knorr chemistry meets contemporary biocatalysis. Threonine dehydrogenase generates aminoacetone from l‐threonine, which is directly intercepted in a chemoenzymatic Knorr pyrrole synthesis. A dual‐function β‐dicarbonyl substrate serves as both pyrrole precursor and hydride acceptor for integrated NAD+ recycling, affording substituted pyrroles ...
Valentina Jurkaš +8 more
wiley +1 more source
Synthesis of pyrroles by nickel-catalysed arylative cyclisations of alkynamides [PDF]
A nickel-based catalytic system for the anti-carbometallative cyclisations of alkynamides to arylboronic acids is described. The reactions proceed using catalytic nickel and (rac)-Ph-PHOX, to provide alkenylnickel species which can undergo reversible E/Z-
Chung, Chieh-Hsu
core
Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups
Angewandte Chemie International Edition, EarlyView.A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari +10 more
wiley +1 more source
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source
BMEMat, EarlyView.ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning +10 more
wiley +1 more source