Results 201 to 210 of about 81,237 (352)

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity

, 2020
Zhanhui Li, Xu Wang, Lin Yu, Yujie Wang, S. C. Wu, Kaijiang Xia, Xu Chen, Haikuo Ma, Jiyue Zheng, Lusong Luo, Fang Zhu, Sudan He, Xiaohu Zhang   +12 more
openalex   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake

Drug Testing and Analysis, Volume 18, Issue 1, Page 159-169, January 2026.
A novel early excreted minor metabolite of LGD‐4033 was detected and coded as M8. Its presence was evaluated as an indicator of recent substance intake versus end‐tail findings. Additionally, the agonist/antagonist properties of M8 and other selected LGD‐4033 metabolites on the androgen receptor (AR) were studied using in silico molecular docking and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Annekathrin M. Keiler, Mario Thevis, Andreas Thomas, Kevin Lam, Gerhard Wolber, Ariadni Vonaparti, Sven Voss, Michael Petrou, Emmanuel N. Pitsinos   +10 more
wiley   +1 more source

Novel Pyrrolidine-Based Pyrazolines as α‑Glucosidase Inhibitors: Microwave-Assisted Synthesis, Antidiabetic Activity, <i>In Silico</i> ADMET Prediction, Molecular Docking, and Molecular Dynamics Simulations. [PDF]

ACS Omega
Kurşun Aktar BS, Sıcak Y, Bakırdöven A, Tatar Yılmaz G, Kaya S, Karaküçük-İyidoğan A, Oruç-Emre EE.   +6 more
europepmc   +1 more source

Untargeted Metabolomics for Diagnosis, Monitoring, and Understanding the Pathophysiology of Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Inherited metabolic disorders (IMDs) encompass a diverse and expanding group of rare diseases caused by genetic disruptions mainly in metabolic enzymes and transporters. Clinical diagnosis of IMDs presents significant challenges due to phenotypic heterogeneity, nonspecific symptoms, and the limited scope of current targeted biochemical assays ...
Jonathan Martens, Udo F. H. Engelke, Ron A. Wevers, Dirk J. Lefeber, Purva Kulkarni   +4 more
wiley   +1 more source

Intelligent design and synthesis of nucleobase and amino acid-based ligands to inhibit the JAK2 enzyme to treat rheumatoid arthritis. [PDF]

Amino Acids
Zarei A, Fatahi A.
europepmc   +1 more source

Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. IX. Synthesis of 1, 1, 5-Trimethyl-2-ethyl-and 1, 1, 2, 4, 5-Pentamethyl-3-diphenylmethylenepyrrolidinium Iodide as Potential Anticholinergic Agents

, 1976
S. OHKI, Yuichiro Yabe, N. OZAWA, Fumiko Hamaguchi   +3 more
openalex   +2 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats. [PDF]

J Transl Med
Hof S, Krüll L, Schmitt J, Neumann C, Marcus C, Kuebart A, Herminghaus A, Relja B, Vollmer C, Bauer I, Picker O, Truse R.   +11 more
europepmc   +1 more source

Concise and Stout Preparation of Spiro[Indazole-3,3'-Pyrrolidine]-2',5'-Diones by a [3+2] Cycloaddition between Α-Arylidene Diazosuccinimides and in Situ Generated Benzynes

Chun-Jun Zhu, Jing-Liang Yu, Yang You, Chun-Chun Tang, Lixin Wang   +4 more
openalex   +1 more source

Chiral hybrid materials based on pyrrolidine building units to perform asymmetric Michael additions with high stereocontrol

, 2018
Sebastián Llopis, Teresa García, Ángel Cantı́n, Alexandra Velty, Urbano Díaz, Avelino Corma   +5 more
openalex   +2 more sources