Results 201 to 210 of about 55,156 (263)

Pyrrolidine analogues of nucleosides and nucleotides

Nucleic Acids Symposium Series, 2008
Among the structurally diverse nucleoside phosphonic acids, several compounds possessing strong antiviral properties have been found. Our effort in this area was focused to the synthesis of novel compounds - pyrrolidine-based nucleoside phosphonic acids and their derivatives.
Dominik, Rejman, Radek, Pohl, Sona, Kovacková, Petr, Kocalka, Alzbĕta, Svenková, Hana, Sanderová, Libor, Krásný, Ivan, Rosenberg   +7 more
openaire   +2 more sources

Diastereoselective Preparation of Azetidines and Pyrrolidines

Organic Letters, 2010
Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative stereochemistry of the iodo-azetidines and pyrrolidines was confirmed by NMR spectroscopy and X-ray
Antonio, Feula, Louise, Male, John S, Fossey   +2 more
openaire   +2 more sources

Synthesis of 3-substituted pyrrolidines

Chemistry of Heterocyclic Compounds, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A. V. Kurkin, E. A. Sumtsova, M. A. Yurovskaya   +2 more
openaire   +1 more source

Synthesis of pyrrolidine-2–14C

Journal of Pharmaceutical Sciences, 1967
The preparation of pyrrolidine-2– 14 C picrate in satisfactory yields from potassium cyanide- 14 C and from barium carbonate- 14 C is reported. Reaction of pyrrolidine picrate with lithium hydroxide followed by distillation separated the free base.
J M, Walts, W V, Kessler, J E, Christian
openaire   +2 more sources

Telescoped Synthesis of Stereodefined Pyrrolidines

Organic Letters, 2013
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %). Using OTMS-quinidine as the Lewis base gives preferential access to an anti-configured pyrrolidine in high enantioselectivity.
Dorine Belmessieri, David B. Cordes, Alexandra M. Z. Slawin, Andrew D. Smith   +3 more
openaire   +2 more sources

Organophosphorus derivatives of pyrrolidine

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1974
Some 2-oxo-2-pyrrolidino-1,3,2-dioxaphospholanes and the corresponding phosphorinanes, and also some 2-thio-2-pyrrolidino-1,3,2-dioxaphospholanes (phosphorinanes), were obtained for the first time. These compounds have an antispasmodic effect and the ability to depress the central nervous system.
N. P. Grechkin, L. N. Grishina
openaire   +1 more source

Removal of the Pyrrolidine Group by Dehydrogenation of a 4-Pyrrolidin-2-yl-tetrahydroisoquinoline

1992
Dehydrogenation of 6,7-dimethoxy-1-methyl-4-(N-methyl-pyrrolidin-2-yl)-3,4-dihydroisoquinoline (9) by Pd/C in tetraline leads to dehydrogenated products, rearrangement, and elimination of the pyrrolidine group mainly as N-methylpyrrolidine (Scheme 3).
Mahboobi, Siavosh, Seidl, E., Eibler, E., Wiegrebe, Wolfgang   +3 more
openaire   +2 more sources

Pulse radiolysis of pyrrolidine.

Radiation research, 1970
The formation, decay, and absorption spectra of transients formed from pyrrolidine in aqueous solutions were studied. The solvated electron ( ${\rm e}_{{\rm aq}}^{-}$) reacts with the protonated and the nonprotonated pyrrolidine forming the ${\rm C}_{4}{\rm H}_{8}{\rm N}$· radical. The rate constants are: $k({\rm e}_{{\rm aq}}^{-}+{\rm C}_{4}{\rm H}_{8}
N, Getoff, F, Schwörer
openaire   +3 more sources

The microwave spectrum of pyrrolidine

Journal of Molecular Spectroscopy, 1984
Abstract The rotational spectra of the normal and N-D isotopic species of pyrrolidine have been measured. The molecule exists in an envelope conformation, with the nitrogen atom out of the plane containing the carbon atoms and with the imino hydrogen in the axial position.
W. Caminati, H. Oberhammer, G. Pfafferott, R.R. Filgueira, C.H. Gomez   +4 more
openaire   +1 more source

New functionalized pyrrolidines

Russian Journal of Organic Chemistry, 2017
New functionalized pyrrolidines have been synthesized from accessible amino acids by the [C+NC+CC]-coupling reaction.
V. A. Egorov, L. S. Khasanova, A. M. Galeeva, F. A. Gimalova, M. F. Abdullin, M. S. Miftakhov   +5 more
openaire   +1 more source