Substituted Spiro[pyrrolidine-5,2'-tricyclo[3.3.1.13,7]decane] Derivatives
Vassil St. Georgiev+5 more
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This review highlights recent advancements in the deconstructive transformation of unstrained cyclic amines, with a particular focus on the C−N bond cleavage of pyrrolidines. Various methodologies, including von Braun‐type, oxidative, and reductive approaches, facilitate the synthesis of diverse amines and the expansion of chemical space.
Eisuke Ota, Junichiro Yamaguchi
wiley +1 more source
Selective C-N Bond Cleavage in Unstrained Pyrrolidines Enabled by Lewis Acid and Photoredox Catalysis. [PDF]
Aida K+6 more
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Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids [PDF]
Dieter Enders, Christoph Thiebes
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Recent Advances in the α‐Hydrazination (α‐Amination) of Carbonyl Compounds
In recent years, notable progress has been achieved in the α‐hydrazination (α‐amination) of carbonyl compounds, especially in the direct asymmetric electrophilic α‐hydrazination with dialkyl azodicarboxylates. This review summarizes all the methods that appeared over the past decade, categorized based on the type of the reactive chiral intermediate ...
Dina Scarpi+2 more
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Kinetic and Theoretical Studies of 3,5-Dicyanothiophene Reactivity with Cyclic Secondary Amines in Water and Acetonitrile: Quantification, Correlation, and Prediction. [PDF]
Hamdi R+7 more
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Benzochalcogenodiazoles, synthesis and applications in medicinal chemistry and photomedicine.
Benzochalcogenodiazoles BXDs (BOD: benzoxadiazole, BTD: benzothiadiazole, or BSD: benzoselenadiazole) are aromatic bicyclic compounds, containing chalcogen atoms, with applications ranging from material to medicinal chemistry. The recent developments in their preparation and functionalization are taking advantage of new methodologies such as C‐H ...
Jean-Elie Zheng+2 more
wiley +1 more source
Novel 5-Oxopyrrolidine-3-carbohydrazides as Potent Protein Kinase Inhibitors: Synthesis, Anticancer Evaluation, and Molecular Modeling. [PDF]
Tumosienė I+5 more
europepmc +1 more source