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Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases
Molecular Biology ReportsPyrroloquinoline quinone (PQQ) is a naturally occurring redox-active compound with potent antioxidant, mitochondrial-enhancing, and neuroprotective properties. Originally identified as a cofactor in bacterial enzymes, PQQ has garnered significant interest for its potential therapeutic role in neurodegenerative diseases, including Alzheimer's disease ...
Tao Xie +3 more
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Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2017
Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. For example, in the process of ADH reaction, alcohol is oxidized to the corresponding aldehyde, and inversely PQQ is reduced to pyrroloquinoline quinol (PQQH2).
K. Ikemoto, Shigeki Mori, K. Mukai
semanticscholar +3 more sources
Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. For example, in the process of ADH reaction, alcohol is oxidized to the corresponding aldehyde, and inversely PQQ is reduced to pyrroloquinoline quinol (PQQH2).
K. Ikemoto, Shigeki Mori, K. Mukai
semanticscholar +3 more sources
Pyrroloquinoline quinone (PQQ): Role in Plant-Microbe Interactions
Secondary Metabolites of Plant Growth Promoting Rhizomicroorganisms, 2019Pyrroloquinoline quinone (PQQ) is synthesized by only some bacteria, but it has an impact on many organisms, including plant growth-promoting bacteria. This molecule can modify some microbial process such as gene expression, metabolism, among others, which have potential advantageous effects on plants.
R. CARREÑO-LÓPEZ +2 more
semanticscholar +2 more sources
Aesthetic surgery journal, 2023
BACKGROUND Reducing absorption after autologous fat grafting is a current challenge. Pyrroloquinoline quinone (PQQ) is the strongest known catalyst for redox reactions, which can scavenge reactive oxygen species (ROS) and alleviate oxidative stress ...
Xiaoyu Zhang +8 more
semanticscholar +1 more source
BACKGROUND Reducing absorption after autologous fat grafting is a current challenge. Pyrroloquinoline quinone (PQQ) is the strongest known catalyst for redox reactions, which can scavenge reactive oxygen species (ROS) and alleviate oxidative stress ...
Xiaoyu Zhang +8 more
semanticscholar +1 more source
ACS Chemical Neuroscience, 2022
Parkinson's disease (PD) is associated with the aggregation and misfolding of a-synuclein (a-syn) protein in dopaminergic neurons. The misfolding process is heavily linked to copper dysregulation in PD.
Shaopei Li +3 more
semanticscholar +1 more source
Parkinson's disease (PD) is associated with the aggregation and misfolding of a-synuclein (a-syn) protein in dopaminergic neurons. The misfolding process is heavily linked to copper dysregulation in PD.
Shaopei Li +3 more
semanticscholar +1 more source
In Analysis, 2021
α-Synuclein (α-syn) is a hallmark protein of Parkinson's disease (PD). The aggregation process of α-syn has been heavily associated with the pathogenesis of PD. With the exponentially growing number of potential therapeutic compounds that can inhibit the
Shaopei Li +3 more
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α-Synuclein (α-syn) is a hallmark protein of Parkinson's disease (PD). The aggregation process of α-syn has been heavily associated with the pathogenesis of PD. With the exponentially growing number of potential therapeutic compounds that can inhibit the
Shaopei Li +3 more
semanticscholar +1 more source
Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™)
Regulatory Toxicology and Pharmacology, 2013The genotoxic potential of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) was evaluated in a battery of genotoxicity tests. The results of the bacterial mutation assay (Ames test) were negative. Weak positive results were obtained in 2 separate in vitro chromosomal aberration test in Chinese hamster lung (CHL) fibroblasts. Upon testing in an in
Masahiko, Nakano +4 more
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Oxidation of polyamines by pyrroloquinoline quinone (PQQ)
Tetrahedron, 1989Abstract Pyrroloquinoline quinone (PQQ) was found to oxidize the polyamines spermine and spermidine in stoichiometric amounts with diaminopropane as the main product identified by reversed phase high performance liquid chromatography and mass spectroscopy of the reaction products.
G. Houen, C. Larsen, L.-I. Larsson
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Pyrroloquinoline quinone (PQQ) prevents fibril formation of α-synuclein
Biochemical and Biophysical Research Communications, 2006Pyrroloquinoline quinone (PQQ) is a noncovalently bound cofactor in the bacterial oxidative metabolism of alcohols. PQQ also exists in plants and animals. Due to its inherent chemical feature, namely its free-radical scavenging properties, PQQ has been drawing attention from both the nutritional and the pharmacological viewpoint.
Masaki, Kobayashi +6 more
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Effects of pyrroloquinoline quinone (PQQ) on skin wound healing in mice.
SurgeryFarshid Davoodi +5 more
semanticscholar +2 more sources