Results 61 to 70 of about 1,834 (157)

Genetic Impacts on the Structure and Mechanics of Cellulose Made by Bacteria

Advanced Science, Volume 12, Issue 33, September 4, 2025.
A genetic mutation in a protease of a cellulose‐overproducing evolved bacterium significantly affects the proteome, structure, and mechanical properties of bio‐fabricated cellulose pellicles. By overexpressing synthase proteins that build the cellulose‐forming biological machinery of the cell, the evolved bacterium generates dense, stiff, and strong ...
Julie M. Laurent, Mathias Steinacher, Anton Kan, Maximilian Ritter, Mario Leutert, Siiri Bienz, David Häberlin, Naresh Kumar, André R. Studart   +8 more
wiley   +1 more source

Interactions of rare earth elements with living organisms and emerging biotechnical applications

PLANTS, PEOPLE, PLANET, Volume 7, Issue 5, Page 1251-1274, September 2025.
Rare earth elements (REEs) are critical resources required to achieve net‐zero carbon emission targets and energy security. However, rising demand for REEs coupled with significant extraction and processing challenges and geopolitical risks restricts access to REE resources.
Samantha A. McGaughey, Shagufta Iqbal, Annamaria De Rosa, Jessica A. Caley, Anna H. Kaksonen, Denys Villa‐Gomez, Caitlin S. Byrt   +6 more
wiley   +1 more source

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease

Advanced Science
Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the potential of ...
Xinuo Li, Yuan Sun, Zheng Zhou, Jinran Li, Sai Liu, Long Chen, Yiting Shi, Min Wang, Zheying Zhu, Guangji Wang, Qiulun Lu   +10 more
doaj   +1 more source

Exploring the Bacterial Microbiota of Seeds

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
The presence of a functional bacterial microbiota in seeds is well established. However, the mechanisms underlying microbial entry into the propagule and its intracellular compartments remain largely unresolved. ABSTRACT The seed microbiota, a still underexplored component of plant–microbe interactions, plays a pivotal role in plant development and ...
Angel J. Matilla
wiley   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, Volume 24, Issue 9, September 2025.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy

Molecules, 2020
Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive to therapeutic intervention.
Qi Zhang, Jing Zhou, Mi Shen, Hui Xu, Shu Yu, Qiong Cheng, Fei Ding   +6 more
doaj   +1 more source

Crystal structure and characterization of pyrroloquinoline quinone disodium trihydrate

Chemistry Central Journal, 2012
Background Pyrroloquinoline quinone (PQQ), a tricarboxylic acid, has attracted attention as a growth factor, and its application to supplements and cosmetics is underway.
Ikemoto Kazuto, Sakamoto Hitoshi, Nakano Masahiko   +2 more
doaj   +1 more source

Role of Two Methanol Dehydrogenases in Methanol Metabolism of Methylobacterium

Shipin gongye ke-ji
In this study, the pyrroloquinoline quinone (PQQ) high-yield mutant J1-1 of Methylobacterium glucophilum MP688 was used to do bioinformatics analysis to extract the two methanol dehydrogenase (MDH) genes from the genome, mpq0771 and mpq2496.
Yaqing GUO, Dongshu WANG, Li ZHU, Weicai ZHANG, Ying LIU, Hengliang WANG   +5 more
doaj   +1 more source

Pyrroloquinoline Quinone (PQQ) Nutritional Status in Humans after Oral Supplementation

The FASEB Journal, 2010
PQQ is a novel growth factor. Reproduction and mitochondrial metabolism are impaired in animals fed diets devoid of PQQ. However, little is known about PQQ functional parameters in humans. In a randomized study, 10 subjects ingested PQQ and were examined at daily/weekly intervals.
Calliandra Harris, Winyoo Chowanadisai, Michael Satre, Kathryn Bauerly, Kathryn Bauerly, Eskouhie Tchaparian   +5 more
openaire   +1 more source