Results 81 to 90 of about 141,799 (322)

My favorite pyruvate carboxylase [PDF]

IUBMB Life, 2010
Having completed a PhD in molecular and cellular biology in mammalian reproduction at the University of Sydney, my first postdoctoral appointment began early in 1965 in the laboratory of Sir Hans Krebs at Oxford University where I had the pleasure of working with Dr Eric Newsholme on the regulation of gluconeogenesis and glycolysis during fetal ...
openaire   +2 more sources

An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution

Advanced Science, EarlyView.
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang, Ting‐Ting Chen, Yu‐Jiao Yang, Yu‐Xi Li, Yi‐Xin Chang, Yan‐Chun Xiao, Wen‐Tai Guo, Ye Zheng, Rui‐Zhe Deng, Yu‐Xiang Tian, Wei Situ, Hong‐Wei Shen, Yu Chen, Ya‐Bin Wang, Jie Xing, Hui Wang, Lin Xia, Yi‐Na Lin, Jian‐Wen Ye   +18 more
wiley   +1 more source

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. [PDF]

, 2015
A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism.
Blair, Ian A, Glickson, Jerry D, Guo, Lili, Henry, Pierre-Gilles, Lee, Seung-Cheol, Leeper, Dennis B, Mancuso, Anthony, Nelson, David S, Roman, Jeffrey C, Shestov, Alexander A   +9 more
core   +2 more sources

From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

Advanced Science, EarlyView.
A comprehensive technology platform enables high‐fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi‐automated computational framework for 3D reconstruction, voxel‐instead of pixel‐based biomarker discovery, and immersive mixed reality data exploration.
Stefania Alexandra Iakab, Jonas Cordes, Thomas Enzlein, Florian Keller, Kevin Kastner, Theresa Mulholland, Björn Christian Fröhlich, Lars Gruber, James Lucas Cairns, Stefan Schmidt, Mathias Hafner, Richard Schneider, Johannes Betge, Frank Fischer, Julian Reichwald, Rüdiger Rudolf, Carsten Hopf   +16 more
wiley   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Vitamin D‐induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities

Animal Models and Experimental Medicine, EarlyView.
Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth, Pathan Amanulla Khan, Jamal‐E‐Fatima, Trupti Pratik Durgawale, Falak Arjumand Siddique, Sharuk L. Khan, Azmath Farhana, Uttam Prasad Panigrahy, Mohammed Abdul Aziz shahid, Mohammed Sayeed, Md. Faysal   +10 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Pyruvate Transport in Isolated Cardiac Mitochondria from two Species of Amphibian Exhibiting Dissimilar Aerobic Scope: Bufo Marinus and Rana Catesbeiana

, 2007
Cardiac mitochondria were isolated from Bufo marinus and Rana catesbeiana, two species of amphibian whose cardiovascular systems are adapted to either predominantly aerobic or glycolytic modes of locomotion.
Duerr, Jeff, Tucker, Kristina
core   +1 more source

Diurnal Changes in Photosynthesis in Sugarcane Leaves: I. Carbon dioxide exchange rate, photosynthetic enzyme activities and metabolite levels relating to the C4 pathway and the Calvin cycle

Plant Production Science, 2000
Diurnal changes in carbon dioxide exchange rate (CER), stomatal conductance (gs), photosynthetic enzyme activities and metabolite levels relating to the C4 pathway and the Calvin cycle in sugarcane (Saccharum sp. cv.
Yu-Chun Du, Akihiro Nose, Ayumu Kondo, Kikuo Wasano   +3 more
doaj   +1 more source

Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

Cancer & Metabolism, 2016
BackgroundThe role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer.
M. Reed, C. Ludwig, C. Bunce, F. Khanim, U. Günther   +4 more
semanticscholar   +1 more source