Results 71 to 80 of about 13,166 (163)

Stimulation of High‐Conductivity Points in Human Skin Reduces Biotin Levels to Modulate Intracellular Metabolism and Local Energy Production

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Acupuncture is a widely used therapeutic practice that targets specific points on or beneath the skin, known as acupoints. While acupoints are thought to exhibit low electrical resistance, their underlying biophysical and molecular characteristics remain incompletely understood.
Kazuki Takagaki, Kristina Todorova, Kentaro Kajiya, Andrea Clocchiatti, Stefano Sol, Fabiana Boncimino, Anna Mandinova   +6 more
wiley   +1 more source

Ketogenic Nutrition in Combination With PPARα Activation Induced Metabolic Failure and Exacerbated Muscle Weakness in Septic Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Suppression of the peroxisome proliferator‐activated receptor alpha (PPARα) has been related to poor outcomes in sepsis and may compromise ketogenesis during critical illness. Infusion of 3‐hydroxybutyrate (3HB) was shown to attenuate muscle weakness in septic mice.
Caroline Lauwers, Wouter Vankrunkelsven, Sarah Derde, Sarah Vander Perre, Inge Derese, Lies Pauwels, Ilse Vanhorebeek, Louis Libbrecht, Pieter Vermeersch, Jan Gunst, Greet Van den Berghe, Michael P. Casaer, Lies Langouche   +12 more
wiley   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

MedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao, Yuan Gao, Xiaolong Yan   +11 more
wiley   +1 more source

mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

MedComm, Volume 6, Issue 12, December 2025.
Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li, Haowei Zhang, Jia Li, Cheng Luo, Zijian Yang, Jin Cai, Li Xia, Yapei Jiang, Ruonan Wang, Hongli Zeng, Yuetong Li, Haitao Yang, Tong Gao, Weidong Xie, Yaou Zhang, Naihan Xu   +15 more
wiley   +1 more source

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Targets and strategies to design soybean seed composition traits

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Breeders and geneticists have put great effort into enhancing soybean seed composition and developing elite varieties with desired traits. However, diverse end‐uses and changing consumer preferences present new challenges and opportunities to develop desired compositional profiles for the market.
Ritesh Kumar, Steven Mulkey, Rahul Mahadev Shelake, Rachel Combs‐Giroir, Thiya Mukherjee, Doug K. Allen, Tom Elmo Clemente, Minviluz G. Stacey, Aaron J. Lorenz, Robert M. Stupar   +9 more
wiley   +1 more source

Biotin Status of Epileptics [PDF]

, 1985
Achuta Murthy P. N., Berlit P., Blass J. P., Bonjour J.-P., Bonjour J.-P., Caspers H., Frigg M., Ghatak N. R., Glaser G. H., Iivanainen M., Johnston D., Krause K.-H., Krause K.-H., Krause K.-H., Meinardi H., Mock D. M., Munoz-Garcia D., Noll F., Patel M. S., Paulsen E. P., Reynolds E. H., Sander J. E., Schmidt D., Scorn D., Selhorst J. B., Sweetman L., Sydenstricker V. P., Thoene J., Vivo D. C., Watanabe T., Wolf B., Woodbury D. M., Woodbury D. M., Woodbury D. M.   +33 more
core   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, Volume 58, Issue 12, December 2025.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source