Results 161 to 170 of about 158,743 (322)

Platform Engineering of Corynebacterium glutamicum with Reduced Pyruvate Dehydrogenase Complex Activity for Improved Production of l -Lysine, l -Valine, and 2-Ketoisovalerate [PDF]

, 2013
Jens Buchholz, Andreas Schwentner, Britta Brunnenkan, Christina Gabris, Simon Grimm, Robert Gerstmeir, Ralf Takors, Bernhard J. Eikmanns, Bastian Blombach   +8 more
openalex   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

USP39 regulates pyruvate handling in non-small cell lung cancer

Cell Death Discovery
The ubiquitin-specific peptidase 39 (USP39) belongs to the USP family of cysteine proteases representing the largest group of human deubiquitinases (DUBs).
Tina Becirovic, Boxi Zhang, Helin Vakifahmetoglu-Norberg, Vitaliy O. Kaminskyy, Elena Kochetkova, Erik Norberg   +5 more
doaj   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Human Serum Mediated Bacteriophage Life Cycle Switch in Aggregatibacter actinomycetemcomitans Is Linked to Pyruvate Dehydrogenase Complex. [PDF]

Life (Basel), 2023
Tang-Siegel GG.
europepmc   +1 more source

Interaction of the components in human and escherichia coli pyruvate dehydrogenase multienzyme complexes

, 2014
Junjie Wang
openalex   +1 more source

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts

, 2011
Lyudmyla G. Glushakova, Sharon Judge, A Teixera da Cruz, Deena Pourang, Clayton E. Mathews, Peter W. Stacpoole   +5 more
openalex   +2 more sources

Long-term regulation of pyruvate dehydrogenase complex. Evidence that kinase-activator protein (KAP) is free pyruvate dehydrogenase kinase [PDF]

, 1991
Bethan S. Jones, Stephen J. Yeaman
openalex   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source