Results 181 to 190 of about 145,751 (270)

Pyruvate dehydrogenase complex deficiency masked by septic shock-induced lactic acidosis: a case report. [PDF]

J Int Med Res
Zhou H, Wen Y, Ding H.
europepmc   +1 more source

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.

Molecules and Cells, 2014
Jun Fan, Changliang Shan, Hee-Bum Kang, Shannon E Elf, Jianxin Xie, M. Tucker, T. Gu, Mike Aguiar, S. Lonning, Huaibin Chen, M. Mohammadi, Laura-Mae P. Britton, B. Garcia, M. Alečković, Yibin Kang, Š. Kaluz, N. Devi, Erwin G. Van Meir, T. Hitosugi, J. Seo, S. Lonial, M. Gaddh, M. Arellano, H. Khoury, F. Khuri, T. Boggon, Sumin Kang, J. Chen   +27 more
semanticscholar   +1 more source

A dendrimer enhanced CRISPR/Cas12a performance for the evaluation of acidogenic capacity in cariogenic bacteria

Interdisciplinary Medicine, EarlyView.
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang, Yining Zhao, Murtaza Sayed, Feng Chen, Juan Zhang   +4 more
wiley   +1 more source

Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency. [PDF]

Hum Mutat
Bruhn H, Naess K, Ygberg S, Peña-Pérez L, Lesko N, Wibom R, Freyer C, Stranneheim H, Wedell A, Wredenberg A.   +9 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1‐13C]‐Pyruvate Studies

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To explore the relationship between potentially rate‐limiting steps in lactate production and the lactate area‐under‐the‐curve (AUC) to pyruvate AUC ratio for analysis of hyperpolarized (HP) [1‐13C]‐pyruvate data. Theory and Methods Simplifying assumptions are introduced to a pharmacokinetic (PK) model with three physical compartments ...
Ryan T. Boyce, Collin J. Harlan, Qing Wang, Christopher M. Walker, Stephen Y. Lai, Matthew E. Merritt, James A. Bankson   +6 more
wiley   +1 more source

Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex. [PDF]

Sci Adv
Meinhold S, Zdanowicz R, Giese C, Glockshuber R.   +3 more
europepmc   +1 more source

Corrigendum: Reprogramming of aerobic glycolysis in non-transformed mouse liver with pyruvate dehydrogenase complex deficiency. [PDF]

Physiol Rep, 2021
europepmc   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Sequential Optimization of Multivariate Metal–Organic Framework Based Biocatalysis

Small, EarlyView.
A sequential Latin hypercube sampling–coupled Bayesian optimization (LHS‐BO) workflow integrates multivariate zirconium‐based metal–organic framework based biocomposite (E‐MOF) design with enzyme biocascade reaction optimization. The optimized E‐MOFs stabilize glucose oxidase and horseradish peroxidase in bioactive conformation, exhibiting high ...
Weibin Liang, Sisi Zheng, Ross Andrew Shalliker, Christian Doonan, Feng Li   +4 more
wiley   +1 more source