Results 11 to 20 of about 158,743 (322)

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency. [PDF]

PLoS ONE, 2015
The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH.
Ana Sofia Rodrigues, Marcelo Correia, Andreia Gomes, Sandro L Pereira, Tânia Perestrelo, Maria Inês Sousa, João Ramalho-Santos   +6 more
doaj   +3 more sources

Abstract P-15: Cryo-Electron Microscopy Study of Dehydrogenase Complexes Interaction with Oxidative Phosphorylation System Supercomplex [PDF]

International Journal of Biomedicine, 2021
Background: Electron transport chain (ETC) complexes, pyruvate dehydrogenase complex (PDC), and α-ketoglutarate dehydrogenase complex (KGDC) are important elements in mitochondrial metabolism.
Konstantin Plokhikh, Roman Kamyshinsky, Yury Chesnokov, Semen Nesterov, Raif Vasilov, Lev Yaguzhinsky   +5 more
doaj   +1 more source

Comparative Analysis of Symmetry Parameters in the E2 Inner Core of the Pyruvate Dehydrogenase Complex. [PDF]

Int J Mol Sci
Kim HU, Jeong MS, An MY, Park YH, Park SH, Chung SJ, Yi YS, Jun S, Kim YK, Jung HS.   +9 more
europepmc   +3 more sources

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts

Cell Reports, 2021
Summary: The pyruvate dehydrogenase complex (PDHc) is a giant enzymatic assembly involved in pyruvate oxidation. PDHc components have been characterized in isolation, but the complex’s quaternary structure has remained elusive due to sheer size ...
Fotis L. Kyrilis, Dmitry A. Semchonok, Ioannis Skalidis, Christian Tüting, Farzad Hamdi, Francis J. O’Reilly, Juri Rappsilber, Panagiotis L. Kastritis   +7 more
doaj   +1 more source

Molecular architecture of mammalian pyruvate dehydrogenase complex. [PDF]

Protein Cell
Chen M, Song Y, Zhang S, Zhang Y, Chen X, Zhang M, Han M, Gao X, Li S, Yang M.   +9 more
europepmc   +3 more sources

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex. [PDF]

Sci Adv
Meinhold S, Zdanowicz R, Giese C, Glockshuber R.   +3 more
europepmc   +3 more sources

Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency

Annals of Internal Medicine: Clinical Cases, 2023
Pyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath ...
Madison B. Calder, Kristen D. Kelley
doaj   +1 more source

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Diabetes & Metabolism Journal, 2023
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee   +4 more
doaj   +1 more source