Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease [PDF]
iScienceSummary: Pyruvate dehydrogenase complex (PDC) is a crucial enzyme that connects glycolysis and the tricarboxylic acid (TCA) cycle pathway. It plays an essential role in regulating glucose metabolism for energy production by catalyzing the oxidative ...
Bo Guo +12 more
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Prenatal presentation of pyruvate dehydrogenase complex deficiency [PDF]
Pediatric Radiology, 2016 We present the case of a female infant referred for prenatal MR evaluation of ventriculomegaly, which had been attributed by the referring obstetrician to aqueductal stenosis. Fetal MR confirmed ventriculomegaly but also demonstrated cerebral volume loss and white matter abnormalities. After birth, the infant developed persistent lactic acidosis.
Niranjana, Natarajan +2 more
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Phenotypic overlap between pyruvate dehydrogenase complex deficiency and FOXG1 syndrome [PDF]
Clinical Case Reports, 2021 Pyruvate dehydrogenase complex (PDHC) deficiency is a mitochondrial disorder. We report two cases of PDHC deficiency with clinical symptoms and brain imaging findings reminiscent of FOXG1 syndrome, suggesting a phenotypic overlap of these disorders.
Yuichi Akaba +6 more
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Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications [PDF]
Cell Reports, 2021 Summary: Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle).
Amitesh Anand +7 more
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GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton [PDF]
Communications Biology, 2022 GDAP1 mutations effect Charcot-Marie-Tooth disease 4A by inhibiting the pyruvate dehydrogenase complex and restricting mitochondrial localization of dynamin-related protein 1 through alterations of the actin cytoskeleton.
Christina Wolf +22 more
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Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency. [PDF]
PLoS ONE, 2015 The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH.
Ana Sofia Rodrigues +6 more
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Phenylbutyrate increases activity of pyruvate dehydrogenase complex
Oncotarget, 2013 Altered metabolism is an important hallmark of cancer cells and confers them a selective advantage for survival and proliferation. Metabolism in cancer cells is shifted towards glycolysis and decreased dependence on mitochondrial glucose oxidation, a phenomenon known as ‘Warburg effect’ (aerobic glycolysis).
Ferriero R, BRUNETTI PIERRI, NICOLA
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Molecular architecture of mammalian pyruvate dehydrogenase complex. [PDF]
Protein CellChen M +9 more
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The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.
Mitochondrion (Amsterdam. Print), 2023 Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi-component megacomplexes provide a crucial mechanistic link between cytoplasmic ...
P. Stacpoole, Charles E. McCall
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The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
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