Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex [PDF]
FEBS Letters, 2008 In human (h) pyruvate dehydrogenase complex (PDC) the pyruvate dehydrogenase (E1) is bound to the E1‐binding domain of dihydrolipoamide acetyltransferase (E2). The C‐terminal surface of the E1β subunit was scanned for the negatively charged residues involved in binding with E2.
Mulchand S. Patel +1 more
openaire +5 more sources
Stoichiometry and architecture of the human pyruvate dehydrogenase complex. [PDF]
Sci AdvThe pyruvate dehydrogenase complex (PDHc) is a key megaenzyme linking glycolysis with the citric acid cycle. In mammalian PDHc, dihydrolipoamide acetyltransferase (E2) and the dihydrolipoamide dehydrogenase-binding protein (E3BP) form a 60-subunit core that associates with the peripheral subunits pyruvate dehydrogenase (E1) and dihydrolipoamide ...
Zdanowicz R +8 more
europepmc +4 more sources
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer [PDF]
PPAR Research, 2017 In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of ...
Yves Lecarpentier +3 more
doaj +4 more sources
Abstract P-15: Cryo-Electron Microscopy Study of Dehydrogenase Complexes Interaction with Oxidative Phosphorylation System Supercomplex [PDF]
International Journal of Biomedicine, 2021 Background: Electron transport chain (ETC) complexes, pyruvate dehydrogenase complex (PDC), and α-ketoglutarate dehydrogenase complex (KGDC) are important elements in mitochondrial metabolism.
Konstantin Plokhikh +5 more
doaj +1 more source
Molecular architecture of mammalian pyruvate dehydrogenase complex. [PDF]
Protein CellChen M +9 more
europepmc +3 more sources
The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj +1 more source
RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen +4 more
doaj +1 more source
LIGHT-SABRE hyperpolarizes 1-^{13}C-pyruvate continuously, without magnetic field cycling [PDF]
J. Phys. Chem. C 2023, 127, 14, 6744-6753, 2023 Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-Pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising molecular imaging agent.
arxiv +1 more source
Annals of Internal Medicine: Clinical Cases, 2023 Pyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath ...
Madison B. Calder, Kristen D. Kelley
doaj +1 more source
The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]
Diabetes & Metabolism Journal, 2023 Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim +4 more
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