Results 31 to 40 of about 96,844 (281)

Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes. [PDF]

, 2012
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes
Wolfgang Eisenreich (108576), Anette Schulz (108573), Andreas Götz (108569), Gillmaier, Nadine, Götz, Andreas, Nadine Gillmaier, Schulz, Anette, Werner Goebel, Goebel, Werner, Eisenreich, Wolfgang, Werner Goebel (7241), Andreas Götz, Anette Schulz, Wolfgang Eisenreich, Nadine Gillmaier (108566)   +14 more
core   +1 more source

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
core   +1 more source

Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex) [PDF]

Biochemical Journal, 1985
The pyruvate dehydrogenase (E1) and acetyltransferase (E2) components of pig heart and ox kidney pyruvate dehydrogenase (PDH) complex were separated and purified. The E1 component was phosphorylated (alpha-chain) and inactivated by MgATP. Phosphorylation was mainly confined to site 1.
A L, Kerbey, P J, Randle
openaire   +2 more sources

Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy

Cell Death and Disease, 2022
The failing heart is characterized by an increase in glucose uptake and glycolytic rates that is not accompanied by a concomitant increase in glucose oxidation.
Jingyu Ni, Hao Zhang, Xiaodan Wang, Zhihao Liu, Tong Nie, Lan Li, Jing Su, Yan Zhu, Chuanrui Ma, Yuting Huang, Jingyuan Mao, Xiumei Gao, Guanwei Fan   +12 more
doaj   +1 more source

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency

JIMD Reports, 2019
Congenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency.
Jirair K. Bedoyan, Leah Hecht, Shulin Zhang, Stacey Tarrant, Ann Bergin, Didem Demirbas, Edward Yang, Ha Kyung Shin, George J. Grahame, Suzanne D. DeBrosse, Charles L. Hoppel, Douglas S. Kerr, Gerard T. Berry   +12 more
doaj   +1 more source

Pyruvate dehydrogenase deficiency: morphological and metabolic effects, creation of animal model to search for curative treatment

Folia Morphologica, 2020
The main source of energy for brain and other organs is glucose. To obtain energy for all tissue, glucose has to come through glycolysis; then as pyruvate it is converted to acetyl-CoA by pyruvate dehydrogenase complex (PDC) and finally enters citric ...
A. Ebertowska, B. Ludkiewicz, I. Klejbor, N. Melka, J. Moryś   +4 more
doaj   +1 more source

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Cells, 2021
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
Edward V. Prochownik, Huabo Wang
doaj   +1 more source

Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol-producing pyruvate decarboxylase pathway

Scientific Reports, 2017
Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to ...
Cathrine E. Fagernes, Kåre-Olav Stensløkken, Åsmund K. Røhr, Michael Berenbrink, Stian Ellefsen, Göran E. Nilsson   +5 more
doaj   +1 more source

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation

Neurobiology of Disease, 2016
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Gonzalo Perez-Siles, Carolyn Ly, Adrienne Grant, Alexander P. Drew, Eppie M. Yiu, Monique M. Ryan, David T. Chuang, Shih-Chia Tso, Garth A. Nicholson, Marina L. Kennerson   +9 more
doaj   +1 more source

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency

Molecular Genetics and Metabolism Reports, 2023
The pyruvate dehydrogenase complex serves as the main connection between cytosolic glycolysis and the tricarboxylic acid cycle within mitochondria. An infant with pyruvate dehydrogenase complex deficiency was treated with vitamin B1 supplementation and a
Eri Ogawa, Takako Hishiki, Noriyo Hayakawa, Hisato Suzuki, Kenjiro Kosaki, Makoto Suematsu, Toshiki Takenouchi   +6 more
doaj   +1 more source