Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications [PDF]
Cell Reports, 2021 Summary: Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle).
Amitesh Anand +7 more
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GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton [PDF]
Communications Biology, 2022 GDAP1 mutations effect Charcot-Marie-Tooth disease 4A by inhibiting the pyruvate dehydrogenase complex and restricting mitochondrial localization of dynamin-related protein 1 through alterations of the actin cytoskeleton.
Christina Wolf +22 more
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Correction: The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation [PDF]
Life Science AllianceMutations in the PDC affect the phosphorylation and mitophagic trafficking of matrix proteins, through the novel regulation of associated kinases and a phosphatase.
Panagiota Kolitsida +6 more
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The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
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RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen +4 more
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Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex [PDF]
FEBS Letters, 2008 In human (h) pyruvate dehydrogenase complex (PDC) the pyruvate dehydrogenase (E1) is bound to the E1‐binding domain of dihydrolipoamide acetyltransferase (E2). The C‐terminal surface of the E1β subunit was scanned for the negatively charged residues involved in binding with E2.
Korotchkina, Lioubov G. +1 more
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Annals of Internal Medicine: Clinical Cases, 2023 Pyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath ...
Madison B. Calder, Kristen D. Kelley
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The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]
Diabetes & Metabolism Journal, 2023 Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim +4 more
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The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex [PDF]
FEBS Letters, 1993 The amino acid sequences of four thiamine pyrophosphate‐requiring enzymes were aligned with the published amino acid sequence of the transketolase of Hansenula polymorpha. Sequences of the combined α and β subunits of the E1 enzyme of the pyruvate dehydrogenase complexes of Homo sapiens and Bacillus stearothermophilus aligned well with the ...
Robinson, Brian H., Chun, Kathy
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Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers [PDF]
Diabetes & Metabolism Journal, 2015 Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction
Nam Ho Jeoung
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