Results 21 to 30 of about 96,844 (281)

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Diabetes & Metabolism Journal, 2023
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee   +4 more
doaj   +1 more source

Inhibition of pyruvate dehydrogenase complex by moniliformin [PDF]

Biochemical Journal, 1986
The mechanism for the inhibition of pyruvate dehydrogenase complex from bovine heart by moniliformin was investigated. Thiamin pyrophosphate proved to be necessary for the inhibitory action of moniliformin. The inhibition reaction was shown to be time-dependent and to follow first-order and saturation kinetics.
P S, Gathercole, P G, Thiel, J H, Hofmeyr   +2 more
openaire   +2 more sources

The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum

Food Production, Processing and Nutrition, 2020
Pyruvate dehydrogenase kinase (PDK) is a mitochondrial enzyme in a variety of eukaryotes, including the plant pathogen Fusarium graminearum. This enzyme can reduce the oxidation of glucose to acetyl-coA by phosphorylation and selectively inhibits the ...
Tao Gao, Dan He, Xin Liu, Fang Ji, Jianhong Xu, Jianrong Shi   +5 more
doaj   +1 more source

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers [PDF]

Diabetes & Metabolism Journal, 2015
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction
Nam Ho Jeoung
doaj   +1 more source

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury

Brain Circulation, 2016
Pyruvate dehydrogenase (PDH) complex is a mitochondrial matrix enzyme that serves a critical role in the conversion of anaerobic to aerobic cerebral energy.
Alexa Thibodeau, Xiaokun Geng, Lauren E Previch, Yuchuan Ding   +3 more
doaj   +1 more source

Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes

Journal of Diabetes Investigation, 2021
Aims/Introduction Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood.
Yuko Nabatame, Tetsuya Hosooka, Chikako Aoki, Yusei Hosokawa, Makoto Imamori, Yoshikazu Tamori, Yuko Okamatsu‐Ogura, Takeshi Yoneshiro, Shingo Kajimura, Masayuki Saito, Wataru Ogawa   +10 more
doaj   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an accessory subunit, E3BP (E3-binding protein). Its icosahedral E2/
Swetha Vijayakrishnan, Byron, Olwyn, Lindsay, J., Gilbert, David, Cooper, Alan, Lindsay, J.G., Nutley, Margaret A, Philip Callow, Byron, O., Callow, P, David Gilbert, Kropholler, P., Callow, Philip, Byron, O, McGow, D., Vijayakrishnan, S, David, Gilbert, Vijayakrishnan, Swetha, McGow, Donna P., Nutley, M.A., Gilbert, D, Callow, P., Kropholler, P, Alan Cooper, Nutley, Margaret A., Cooper, A., Donna P. McGow, Lindsay, J Gordon, Nutley, M., Lindsay, J. Gordon, Cooper, A, J. Gordon Lindsay, Vijayakrishnan, S., McGow, DP, Margaret A. Nutley, Olwyn Byron, Kropholler, Peter, Peter Kropholler, Mcgow, Donna P, Lindsay, JG, Nutley, MA, McGow, D.P., Gilbert, D.   +42 more
core   +1 more source

Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis

Frontiers in Pharmacology, 2019
Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes.
Majid Ghareghani, Majid Ghareghani, Linda Scavo, Linda Scavo, Yahya Jand, Naser Farhadi, Hossein Sadeghi, Amir Ghanbari, Stefania Mondello, Stefania Mondello, Damien Arnoult, Sajjad Gharaghani, Kazem Zibara, Kazem Zibara   +13 more
doaj   +1 more source

Regulation of Cardiac-Specific Proteins Expression by Moderate-Intensity Aerobic Exercise Training in Mice With Myocardial Infarction Induced Heart Failure Using MS-Based Proteomics

Frontiers in Cardiovascular Medicine, 2021
This study aims to systematically reveal the changes in protein levels induced by regular exercise in mice with ischemic-induced heart failure (HF). Aerobic exercise training for the ischemic-induced HF mice lasted for 4 weeks and then we used the liquid
Shouling Mi, Shouling Mi, Hao Jiang, Hao Jiang, Lei Zhang, Zhonglei Xie, Zhonglei Xie, Jingmin Zhou, Jingmin Zhou, Aijun Sun, Aijun Sun, Aijun Sun, Hong Jin, Hong Jin, Junbo Ge, Junbo Ge, Junbo Ge   +16 more
doaj   +1 more source

Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis [PDF]

, 2013
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Bohne, Alexandra-Viola, Marco Schottkowski, Michael Lidschreiber, Zerges, William, Markus Piotrowski (169373), Markus Piotrowski, Michael Lidschreiber (138963), Christian Schwarz, Alexandra-Viola Bohne (281295), Marco Schottkowski (281297), William Zerges, Nickelsen, Jörg, Jörg Nickelsen (13576), Piotrowski, Markus, Alexandra-Viola Bohne, Christian Schwarz (281296), Lidschreiber, Michael, Jörg Nickelsen, Schottkowski, Marco, Schwarz, Christian, William Zerges (95563)   +20 more
core   +1 more source