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A mimic of the pyruvate dehydrogenase complex
Bioorganic & Medicinal Chemistry Letters, 2010Pyruvic acid undergo decarboxylation catalyzed by a hydrophobic thiazolium salt and reacts with a hydrophobic analog of lipoic acid to form a hydrophobic acylthioester that reacts with aniline to form acetanilide in water, but only in the presence of a hydrophobically modified polyaziridine that acts to gather the reactants just as the enzyme complex ...
Huanyu, Zhao, Ronald, Breslow
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Experimental Cell Research, 1984
The fermentative mycoplasmas A. laidlawii JS, M. hyorhinis DBS-50, M. hyorhinis GDL and M. pneumoniae FH have very high apparent activities of pyruvate dehydrogenase (PDH) (EC 1.2.4.1) and pyruvate dehydrogenase complex (PDHC). Infection of normal and PDHC-deficient fibroblasts with these mycoplasma species resulted in a marked increase of the specific
G J, McGarrity +2 more
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The fermentative mycoplasmas A. laidlawii JS, M. hyorhinis DBS-50, M. hyorhinis GDL and M. pneumoniae FH have very high apparent activities of pyruvate dehydrogenase (PDH) (EC 1.2.4.1) and pyruvate dehydrogenase complex (PDHC). Infection of normal and PDHC-deficient fibroblasts with these mycoplasma species resulted in a marked increase of the specific
G J, McGarrity +2 more
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Biochemistry, 1977
One sulfhydryl group per polypeptide chain of the pyruvate dehydrogenase component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli was selectively labeled with N-[P-(2-benzoxazoyl)phenyl]-maleimide (NBM), 4-dimethylamino-4-magnitude of-maleimidostilbene (NSM), and N-(4-dimethylamino-3,5-dinitrophenyl)maleimide (DDPM) in 0.05 M ...
N, Papadakis, G G, Hammes
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One sulfhydryl group per polypeptide chain of the pyruvate dehydrogenase component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli was selectively labeled with N-[P-(2-benzoxazoyl)phenyl]-maleimide (NBM), 4-dimethylamino-4-magnitude of-maleimidostilbene (NSM), and N-(4-dimethylamino-3,5-dinitrophenyl)maleimide (DDPM) in 0.05 M ...
N, Papadakis, G G, Hammes
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Regulation of the Human Pyruvate Dehydrogenase Complex
Clinical Science, 19761. The pyruvate dehydrogenase complex from human heart has been partially purified and shown to be regulated by a phosphorylation-dephosphorylation cycle similar to that previously found for other mammalian tissues. 2. Incubation of the complex with ATP (2 mmol/l) led to its inactivation associated with the concomitant incorporation into
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[Pyruvate dehydrogenase complex deficiency].
Nihon rinsho. Japanese journal of clinical medicine, 2002M, Ito, Y, Kuroda
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Pyruvate dehydrogenase complex from Bacillus.
Methods in enzymology, 1982Visser, J. +3 more
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Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity
Cell, 2014Rommel A Mathias +2 more
exaly

