Results 21 to 30 of about 425,123 (370)
The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex [PDF]
FEBS Letters, 1993 The amino acid sequences of four thiamine pyrophosphate‐requiring enzymes were aligned with the published amino acid sequence of the transketolase of Hansenula polymorpha. Sequences of the combined α and β subunits of the E1 enzyme of the pyruvate dehydrogenase complexes of Homo sapiens and Bacillus stearothermophilus aligned well with the ...
Brian H. Robinson, Kathy Chun
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Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers [PDF]
Diabetes & Metabolism Journal, 2015 Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction
Nam Ho Jeoung
doaj +1 more source
Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes
Journal of Diabetes Investigation, 2021 Aims/Introduction Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood.
Yuko Nabatame +10 more
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Immunological studies with pyruvate dehydrogenase complex [PDF]
Fungal Genetics Reports, 1972 Immunological studies with pyruvate dehydrogenase ...
R. W. Harding, R. P. Wagner
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Inhibition of pyruvate dehydrogenase complex by moniliformin [PDF]
Biochemical Journal, 1986 The mechanism for the inhibition of pyruvate dehydrogenase complex from bovine heart by moniliformin was investigated. Thiamin pyrophosphate proved to be necessary for the inhibitory action of moniliformin. The inhibition reaction was shown to be time-dependent and to follow first-order and saturation kinetics.
P G Thiel, J H S Hofmeyr, P S Gathercole
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Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
Brain Circulation, 2016 Pyruvate dehydrogenase (PDH) complex is a mitochondrial matrix enzyme that serves a critical role in the conversion of anaerobic to aerobic cerebral energy.
Alexa Thibodeau +3 more
doaj +1 more source
Food Production, Processing and Nutrition, 2020 Pyruvate dehydrogenase kinase (PDK) is a mitochondrial enzyme in a variety of eukaryotes, including the plant pathogen Fusarium graminearum. This enzyme can reduce the oxidation of glucose to acetyl-coA by phosphorylation and selectively inhibits the ...
Tao Gao +5 more
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Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1- 13 C]pyruvate [PDF]
, 2021 ParaHydrogen Induced Polarization-Side Arm Hydrogenation (PHIP-SAH) is an inexpensive tool to obtain hyperpolarized pyruvate (and other metabolites) that can be applied to in-vivo diagnostics, for the investigation of metabolic processes. This method is based on hydrogenation, using hydrogen enriched in the para-isomer, of unsaturated substrates ...
arxiv +1 more source
Frontiers in Pharmacology, 2019 Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes.
Majid Ghareghani +13 more
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BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]
, 2014 While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P. +11 more
core +1 more source