Cancer & Metabolism, 2019 Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu +6 more
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Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors
Angewandte Chemie International Edition, Accepted Article.High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li +10 more
wiley +1 more source
Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply [PDF]
, 2000 Mary C. Sugden +3 more
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Nature CommunicationsHumans have, throughout history, faced periods of starvation necessitating increased physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 males and 6 females) fasted for seven days. They lost 4.6 ± 0.3 kg lean and
Kristoffer J. Kolnes +16 more
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Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments [PDF]
, 1979 Michael A. Baxter +2 more
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Hepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review
Animal Research and One Health, EarlyView.phosphoenolpyruvate carboxy kinase, FBP1, and glucose‐6‐phosphatase are key rate‐limiting enzymes that determine the efficiency of gluconeogenesis. The main substrate for gluconeogenesis in the liver of ruminants is propionate, which provides more than 60% of the carbon source for gluconeogenesis.
Guoyan Wang +5 more
wiley +1 more source
Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase [PDF]
, 1992 O J Park +5 more
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Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant
Biotechnology and Bioengineering, EarlyView.ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida +7 more
wiley +1 more source
Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism
Journal of Lipid Research, 1970 The effect of diet on the desaturation of linoleic acid to gamma-linolenic acid by liver microsomal preparations, on blood glucose and insulin levels, and on activities of glucokinase, hexokinase, pyruvate kinase, and alpha-glycerophosphate dehydrogenase
I.N. De Gomez Dumm +2 more
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Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase [PDF]
, 1994 David A. Priestman +3 more
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