Results 291 to 300 of about 181,145 (327)

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
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Inhibition of pyruvate dehydrogenase kinase 4 attenuates myocardial and mitochondrial injury in sepsis-induced cardiomyopathy.

Journal of Infectious Diseases, 2023
BACKGROUND Sepsis-induced cardiomyopathy (SIC) is a cardiac dysfunction caused by sepsis, with mitochondrial dysfunction being a critical contributor. Pyruvate dehydrogenase kinase 4 (PDK4) is a kinase of pyruvate dehydrogenase (PDH) with multifaceted ...
Tangtian Chen, Liang Ye, Jing Zhu, B. Tan, Qin Yi, Yanting Sun, Qiu-ping Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu   +10 more
semanticscholar   +1 more source

Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer

Journal of Biomolecular Structure and Dynamics, 2020
Pyruvate dehydrogenase kinase 3 (PDK3) is a multifunctional enzyme that plays a central role in the cancer metabolic switch by blocking pyruvate catabolism in the TCA cycle. PDK3 plays a significant role in the TCA cycle and cancer cell progression, thus,
Taj Mohammad, Kaynat Arif, M. Alajmi, A. Hussain, A. Islam, M. Rehman, M. Hassan   +6 more
semanticscholar   +1 more source

Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease

Nephrology, 2020
Muscle weakness is commonly among chronic kidney disease (CKD) patients. Muscle mitochondrial dysfunction and decreased pyruvate dehydrogenase (PDH) activity occur in CKD animals but have not been confirmed in humans, and changes in pyruvate ...
Chenqi Xu, Ayijiaken Kasimumali, Xiangjiang Guo, R. Lu, K. Xie, Mingli Zhu, Yingying Qian, Xiaohuan Chen, H. Pang, Qin Wang, Z. Fan, H. Dai, S. Mou, Z. Ni, L. Gu   +14 more
semanticscholar   +1 more source

Synthetic peptide substrates for mammalian pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase

Archives of Biochemistry and Biophysics, 1985
The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
T R, Mullinax, L R, Stepp, J R, Brown, L J, Reed   +3 more
openaire   +2 more sources

Inhibition of mitochondrial pyruvate dehydrogenase kinase: a proposed mechanism by which melatonin causes cancer cells to overcome cytosolic glycolysis, reduce tumor biomass and reverse insensitivity to chemotherapy

Melatonin Research, 2019
This review presents a hypothesis to explain the role of melatonin in regulating glucose metabolism in cancer cells.  Many cancer cells use cytosolic glycolysis (the Warburg effect) to produce energy (ATP).
R. Reiter, Ramaswamy Sharma, Q. Ma, S. Rosales‐Corral, D. Acuña-Castroviejo, G. Escames   +5 more
semanticscholar   +1 more source

Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable

Biochemical and Biophysical Research Communications, 1985
Pyruvate inhibited pyruvate dehydrogenase kinase activity in mitochondria from adipose tissue, heart, brain and kidney of fed rats. Starvation for 24 h led to increased kinase activity in mitochondria from adipose tissue and heart but not from brain or kidney and to reduction of pyruvate inhibition of the enzyme from adipose tissue, heart and brain ...
D, Lyn, H G, Coore
openaire   +2 more sources

Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart

Molecular and Cellular Biochemistry, 1995
Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
T C, Carter, H G, Coore
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Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase

Biochemical and Biophysical Research Communications, 1977
Abstract Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate dehydrogenase phosphatase and that the dephosphopeptides can serve as substrates for pyruvate dehydrogenase kinase.
P F, Davis, F H, Pettit, L J, Reed
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Histidine Modifying Agents Abolish Pyruvate Dehydrogenase Kinase Activity

Biochemical and Biophysical Research Communications, 2000
Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1alpha subunit of the pyruvate dehydrogenase complex (PDC). Sequence analysis of cloned PDKs led to the proposal that they are mechanistically related to prokaryotic 2-component His-kinases.
B P, Mooney, N R, David, J J, Thelen, J A, Miernyk, D D, Randall   +4 more
openaire   +2 more sources