Results 291 to 300 of about 234,539 (335)

Hydrogel Viscoelasticity Modulates Cell Nascent Extracellular Matrix Deposition

Macromolecular Rapid Communications, EarlyView.
In this study, interpenetrating polymer network hydrogels with tunable viscoelastic properties were developed to study the mechanical regulation of nascent extracellular matrix (nECM) deposition. Cells cultured on high‐viscosity (high tanδ) hydrogels deposited more nECM and increased hydrogel remodeling independent of cellular contraction forces. These
Matthew L. Tan, Avinava Roy, Eleanor M. Plaster, Haguy Wolfenson, Adam Abraham, Claudia Loebel   +5 more
wiley   +1 more source

Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation. [PDF]

Blood Adv
Le K, Wang X, Chu J, Lundt M, Lee YY, Conrey A, Frey I, Giannini S, Kosinski PA, Hausman JM, Low PS, Jeffries N, Desai SA, Thein SL.   +13 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Pyruvate Kinase M1/2 Proteoformics for Accurate Insights into Energy Metabolism Abnormity to Promote the Overall Management of Ovarian Cancer Towards Predictive, Preventive, and Personalized Medicine Approaches. [PDF]

Metabolites
Wang Y, Xu N, Ndzie Noah ML, Chen L, Zhan X.   +4 more
europepmc   +1 more source

Interactions of tumor necrosis factor receptor-associated factor 4 and pyruvate kinase muscle isoform 2 promote malignant behavior and aerobic glycolysis in colorectal cancer cells. [PDF]

Cytojournal
Liu T, Zhu S, Sun J, Ma Y.
europepmc   +1 more source

Pyruvate Kinase M2-Responsive Release of Paclitaxel and Indoleamine 2,3-Dioxygenase Inhibitor for Immuno-Chemotherapy of Nonsmall Cell Lung Cancer. [PDF]

Adv Sci (Weinh)
Wu H, Sun X, Li K, Li J, Jiang H, Yan D, Lin Y, Ding Y, Lu Y, Zhu X, Chen X, Li X, Liang G, Xu H.   +13 more
europepmc   +1 more source

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2. [PDF]

Nat Commun
Wang RH, Chen PR, Chen YT, Chen YC, Chu YH, Chien CC, Chien PC, Lo SY, Wang ZL, Tsou MC, Chen SY, Chiu GS, Chen WL, Wu YH, Wang LH, Wang WC, Lin SY, Kung HJ, Wang LH, Cheng HC, Lin KT.   +20 more
europepmc   +1 more source

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Mutations in pyruvate kinase

Human Mutation, 1996
Pyruvate kinase (PK) deficiency due to mutations of the PKLR gene is a common cause of hereditary nonspherocytic hemolytic anemia. Thus far, 55 different mutations have been described in patients with PK-deficient hemolytic anemia. Polymorphisms within the PKLR gene and in the tightly linked glucocerebrosidase (GBA) gene suggest that PK deficiency may ...
Ernest Beutler, Luciano Baronciani
openaire   +3 more sources