Results 211 to 220 of about 51,864 (248)

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Nature, 2008
Growth factors stimulate cells to take up excess nutrients and to use them for anabolic processes. The biochemical mechanism by which this is accomplished is not fully understood but it is initiated by phosphorylation of signalling proteins on tyrosine residues.
Heather R, Christofk, Matthew G, Vander Heiden, Ning, Wu, John M, Asara, Lewis C, Cantley   +4 more
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Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics

Cancer Letters, 2021
Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in ...
Susi, Zhu, Yeye, Guo, Xu, Zhang, Hong, Liu, Mingzhu, Yin, Xiang, Chen, Cong, Peng   +6 more
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Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle

Current Drug Targets, 2023
Abstract: Pyruvate kinase M2 (PKM2) has surfaced as a potential target for anti-cancer therapy. PKM2 is known to be overexpressed in the tumor cells and is a critical metabolic conduit in supplying the augmented bioenergetic demands of the recalcitrant cancer cells.
Saumya, Kapoor, Deep Rohan, Chatterjee, Moumita Ghosh, Chowdhury, Rudradip, Das, Amit, Shard   +4 more
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Role of Pyruvate Kinase M2 (PKM2) in Cardiovascular Diseases

Journal of Cardiovascular Translational Research, 2022
Cardiovascular diseases (CVDs) are the world's leading cause of death, accounting for 32% of all fatalities. Although therapeutic agents are available for CVDs, however, most of them have significant limitations such as the time-dependency effect, hypotension, and bradycardia.
Mohd, Rihan, Shyam Sunder, Sharma
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Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

Journal of Medicinal Chemistry, 2019
As cancer cells undergo metabolic reprogramming in the course of tumorigenesis, targeting energy metabolism represents a promising strategy in cancer therapy. Among various metabolic enzymes examined, pyruvate kinase M2 type (PKM2) has received much attention in light of its multifaceted function in promoting tumor growth and progression. In this study,
I-Shan Hsieh, Balraj Gopula, Chi-Chi Chou, Hsiang-Yi Wu, Geen-Dong Chang, Wen-Jin Wu, Chih-Shiang Chang, Po-Chen Chu, Ching S. Chen   +8 more
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Pyruvate Kinase Type Tumor M2 in Urological Malignancies

Urologia Internationalis, 2003
<i>Introduction: </i>The dimeric form of pyruvate kinase type M2 is overexpressed in tumor cells (TuM2-PK). The aim of the present study was to evaluate the clinical value of TuM2-PK as a tumor marker for renal cell carcinoma (RCC), transitional cell carcinoma of the bladder (TCC) and prostate cancer (PCA) by using a commercially available ...
A, Hegele, Z, Varga, B, Kosche, T, Stief, A, Heidenreich, R, Hofmann   +5 more
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Tumour M2-pyruvate kinase: a gastrointestinal cancer marker

European Journal of Gastroenterology & Hepatology, 2007
Gastrointestinal cancer tumour markers are valuable in the detection of recurrence following resection or in monitoring response to chemotherapy. CEA, CA19-9, CA-50 and CA72-4 are currently available but are nonspecific and have a low sensitivity. 'Tumour M2-pyruvate kinase' was described by Eigenbrodt around 1985. In cancers the active tetrameric form
Yogesh, Kumar, Niteen, Tapuria, Naveed, Kirmani, Brian R, Davidson   +3 more
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Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation

Inflammatory Bowel Diseases, 2007
Surrogate markers of bowel inflammation are increasingly being recognized as important, not only as markers of disease activity in inflammatory bowel disease (IBD) but also to differentiate irritable bowel syndrome (IBS) from IBD. The dimeric M2-isoform of pyruvate kinase (M2-PK) has been reported to be elevated in fecal specimens from colorectal ...
Guy, Chung-Faye, Bu'hussain, Hayee, Susan, Maestranzi, Nora, Donaldson, Ian, Forgacs, Roy, Sherwood   +5 more
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Pyruvate Kinase M2: A Metabolic Tuner

2015
Metabolic enzymes are emerging as key mediators in modifying cell metabolism in response to extracellular signals, such as growth factors which trigger the upregulation of a specific isoform of pyruvate kinase (PK) M2. PKM2 alters its own catalytic activity by many different ways, and one of these involves the switch in the degree of oligomerization ...
Vibhor Gupta, Mohd Askandar Iqbal, Bhupender Kumar, Rameshwar N. K. Bamezai   +3 more
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The SUMO‐E3 ligase PIAS3 targets pyruvate kinase M2

Journal of Cellular Biochemistry, 2009
AbstractPyruvate kinase M2 (M2‐PK) controls the rate‐limiting step at the end of the glycolytic pathway in normal proliferating and tumor cells. Other functions of M2‐PK in addition to its role in glycolysis are little understood. The aim of this study was to identify new cellular interaction partners of M2‐PK in order to discover novel links between ...
Gilles A, Spoden, Dieter, Morandell, Daniela, Ehehalt, Marc, Fiedler, Pidder, Jansen-Dürr, Martin, Hermann, Werner, Zwerschke   +6 more
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