Results 101 to 110 of about 2,934 (256)

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-13C‑Acetates and 1-13C‑Pyruvates via Side Arm Hydrogenation

ACS Omega, 2018
Nikita V. Chukanov, Oleg G. Salnikov, Roman V. Shchepin, Kirill V. Kovtunov, Igor V. Koptyug, Eduard Y. Chekmenev   +5 more
doaj   +1 more source

Visible-light induced click reactions of acylsilanes with pyruvate electrophiles. [PDF]

Chem Sci
Pilkington RL, Kössler R, Molloy J, Bräse S, Priebbenow DL.   +4 more
europepmc   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Host metabolism can produce many indoles and phenols independently of the microbiome. [PDF]

Nat Metab
AbuSalim JE, Olszewski K, Youssef S, Mitchell SJ, Hunter CJ, Little J, Sidebottom A, Boyer JA, Knutson SD, Samarah LZ, MacArthur MR, Henneberg AL, Ryseck RP, Opitz CA, MacMillan DWC, Donia MS, Pamer EG, Imam S, Lehmann CJ, Odenike O, Rabinowitz JD.   +20 more
europepmc   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Metabolic origins of hyperoxaluria: the critical role of precursors and vitamin B6 status in rats. [PDF]

Urolithiasis
Ogawa Y.
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron-Deficient Aromatic d-Amino Acids. [PDF]

Angew Chem Int Ed Engl
Buslov I, Desmons S, Wang W, Massaad LE, Hu X.   +4 more
europepmc   +1 more source

Novel 1,2,3-Triazole Derivatives as Antimicrobial Agents

, 2014
2-Substituted benzimidazoles 3a-c was prepared via condensation of ethyl pyruvates 2a-c with 2-phenylenediamine in glacial acetic acid. Pyrrolo[1,2-a]benzimidazole derivatives 5 and 8 were prepared via cyclocondensation of compounds 3a,b with phosphorus ...
Mohamed, Hanan A.; National Research Centre, Abdel-Wahab, Bakr F.; National Research Centre, Awad, Ghada E.A.; National Research Center   +2 more
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