Results 131 to 140 of about 2,702 (229)

Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation. [PDF]

J Nanobiotechnology
Tu M, Deng X, Zhou Z, Li X, Mao S, Lai B, Pang L, Zhong Q, Cao J, Liu H, Ouyang X.   +10 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome. [PDF]

J Anim Sci Biotechnol
Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, Ikeda-Ohtsubo W, Agista AZ, Yoshida A, Sakuma T, Fukuda I, Suzuki K, Yoshioka G, Imai Y, Tsuchida S, Nishiyama E, Shinkai H, Muneta Y, Uenishi H, Tobe R, Shirakawa H, Maekawa M, Mano N, Kitazawa H, Nishiyama K.   +23 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification. [PDF]

Cell Death Dis
Lin HA, Lin HC, Tsai MH, Chen YJ, Bao BY, Tsai KJ, Shih CT, Yu JS, Chien KY, Huang KY, Ojcius DM, Chen LC.   +11 more
europepmc   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Glucose transporter 2‑transported glucosamine inhibits glycolysis in cancer cell lines through competition with glucose for hexokinase II. [PDF]

Oncol Rep
Park SY, Song KH, Kang JH, Oh SH.
europepmc   +1 more source

The Estimation of Pyruvic Acid [PDF]

Biochemical Journal, 1913
openaire   +2 more sources

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

Advanced Science, EarlyView.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li, Jun‐Jie Zhangyang, Bing‐Zhi Li, Zhi‐Hua Liu, Ying‐Jin Yuan   +4 more
wiley   +1 more source

Efficacy of Phage Cocktails Against Biofilms Formed by Antibiotic-Resistant Bacteria. [PDF]

Infect Drug Resist
Poniatovskyi V, Shyrobokov V, Vodianyk A, Kharina A, Shevchenko O.   +4 more
europepmc   +1 more source