Results 201 to 210 of about 2,934 (256)

The development of the occurrence and metastasis of breast cancer by single-cell sequencing. [PDF]

Cancer Cell Int
Chen M, Feng M, Lei H, Dan Mo, Ren S, Yang D.   +5 more
europepmc   +1 more source

Control of Reactions of Pyruvates by Catalysts: Direct Enantioselective Mannich Reactions of Pyruvates Catalyzed by Amine-Based Catalyst Systems

Organic Letters, 2022
Enantioselective Mannich reactions of pyruvates catalyzed by amine-based catalyst systems, in which pyruvates act as nucleophiles, are reported. The reactions of pyruvates and cyclic sulfonylimines afforded the desired Mannich products, including those ...
Ravindra D Aher, Fujie Tanaka, Kenji Monde   +2 more
exaly   +2 more sources

Heck Reaction of 2-Oxyacrylates With Aryl Bromides: A Common Route to Monoaryl Pyruvates and Ortho Ester-Protected Monoaryl Pyruvates

Journal of Organic Chemistry, 2022
A palladium-catalyzed Heck reaction between 2-oxyacrylates and aryl bromides was developed, where DavePhos was a unique ligand that efficiently promoted the reaction.
Duc N Tran, Kiran Matcha, Kévin Jouvin
exaly   +2 more sources

Asymmetric Organocatalytic Reductive Coupling Reactions Between Benzylidene Pyruvates and Aldehydes [PDF]

Organic Letters, 2016
An organocatalytic three-component reductive coupling reaction between dimethyl phosphite, benzylidene pyruvates, and aldehydes is reported. A chiral triaryl­iminophos­phorane catalyst promotes Pudovik addition, which is followed by phospha-Brook ...
Jeffrey S. Johnson, Matthew A Horwitz
exaly   +3 more sources

Catalytic Enantioselective Aldol Reactions of Pyruvates as Nucleophiles With Chlorinated and Fluorinated Aldehydes and Ketones [PDF]

Journal of Organic Chemistry
Reactions of pyruvates as nucleophiles under catalytic conditions are difficult to control without the use of enzymes as catalysts. Here, enantioselective aldol reactions of pyruvates with chlorinated and fluorinated aldehydes and ketones under ...
Fujie Tanaka, Santanu Mondal
exaly   +2 more sources

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Substrate activation of pyruvate carboxylase by pyruvate

Biochemical and Biophysical Research Communications, 1969
Abstract A kinetic analysis of pyruvate carboxylase isolated from sheep liver and using pyruvate as the variable substrate revealed non-Michaelis Menten kinetic. Double reciprocal plots were biphasic and R S values of 222 were obtained. Hill plots prepared from the initial velocity data showed that at low pyruvate concentrations, the slope of the ...
H, Taylor, J, Nielsen, D B, Keech
openaire   +2 more sources

Pyruvate carboxylase

The International Journal of Biochemistry & Cell Biology, 1998
Pyruvate carboxylase [EC 6.4.1.1] is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several
Wallace, J., Jitrapakdee, S., Chapman-Smith, A.   +2 more
openaire   +3 more sources

Amperometric sensor for pyruvate with immobilized pyruvate oxidase

Analytica Chimica Acta, 1987
Abstract Several procedures for immobilization of pyruvate oxidase by chemical bonding are reported. Attachment to nylon net was unsatisfactory in terms of yield and stability. Polyazetidine, a new commercially available prepolymer and a new nylon membrane with surface carboxyl groups provided good long-term stability, up to 30 days in the case of ...
M. Mascini, MAZZEI, Franco
openaire   +1 more source

Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex

Journal of Inherited Metabolic Disease, 1996
Summary The most common defect associated with deficiency of the pyruvate dehydrogenase (PDH) complex occurs in the E 1 component, specifically due to mutations in the X‐linked E 1 α gene. Clinical sequelae of these
B H, Robinson, N, MacKay, K, Chun, M, Ling   +3 more
openaire   +2 more sources

Pyruvate carboxylase deficiency

Journal of Inherited Metabolic Disease, 1984
AbstractThe causes of congenital lactic acidaemia are outlined. Isolated pyruvate carboxylase deficiency is reviewed in detail with a report of a recent case and a discussion of the biochemical consequences. Other causes of defective pyruvate carboxylation are described, particularly the combined carboxylase defects.
K, Bartlett, H K, Ghneim, J H, Stirk, G, Dale, K G, Alberti   +4 more
openaire   +2 more sources