Results 71 to 80 of about 89,552 (236)
Asymmetric Mannich reactions of α-ketoesters catalyzed through noncovalent interactions: Differences between pyruvates and substituted pyruvates in the formation of nucleophilic species [PDF]
Diastereo- and enantioselective Mannich reactions of substituted pyruvates or α-ketoester derivatives that are larger than 2-oxopropanoates catalyzed by a tertiary amine derivative bearing functional groups that can form hydrogen bonds are described.
Mondal, Santanu, Tanaka, Fujie
core
Advanced Materials, EarlyView.Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn +17 more
wiley +1 more source
Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis
Advanced Materials, EarlyView.Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne +12 more
wiley +1 more source
Advanced Materials, EarlyView.Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner +10 more
wiley +1 more source
Challenging Structure Elucidator
, 2011 This chapter will review examples of challenges solved using StrucEluc and will demonstrate all of the diverse approaches for computer assisted structure elucidation discussed in this volume.
core +1 more source
Advanced Robotics Research, EarlyView.An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy +13 more
wiley +1 more source
Journal of Biological Chemistry, 1958 The enol tautomers of the aromatic oc-keto acids combine instantaneously and reversibly with borate to form complexes of a mixed ester-anhydride structure, thereby displacing the apparent keto-enol equilibrium in favor of the enol tautomer.
E. Lin, B. Pitt, Morton Civen, W. Knox
semanticscholar +1 more source
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Synthesis of 4-Substituted-Pyridine-2,6-dicarboxylic Acid Derivatives from Pyruvates and Aldehydes in One Pot [PDF]
4-Substituted-pyridine-2,6-dicarboxylic acid derivatives were synthesized in one pot under mild conditions via the formation of dihydropyran derivatives from pyruvates and aldehydes catalyzed by pyrrolidine-acetic acid, followed by the reaction with ...
Lapointe, Sébastien +2 more
core
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source