Results 131 to 140 of about 10,281 (182)

A new molecular form of PYY: Structural characterization of human PYY(3–36) and PYY(1–36)

Peptides, 1989
A radioimmunoassay was developed using an antibody raised in rabbits against synthetic porcine PYY. This radioimmunoassay was used to detect PYY immunoreactivity in human intestinal extracts. Human colonic mucosa was extracted with acid, centrifuged and the supernatant concentrated by low pressure preparative reverse phase chromatography.
Viktor Eysselein, John E Shively, Peter Layer   +2 more
exaly   +3 more sources

The role of PYY in feeding regulation

Regulatory Peptides, 2008
Peptide YY (PYY), a 36-amino-acid peptide, is secreted primarily from L-cells residing in the intestinal mucosa of the ileum and large intestine. PYY, which belongs to a family of peptides including neuropeptide Y (NPY) and pancreatic polypeptide, is released into the circulation as PYY(1-36) and PYY(3-36); the latter is the major form of PYY in gut ...
Msamitsu Nakazato, Hiroaki Ueno, Masanari Mizuta   +2 more
exaly   +3 more sources

Structural characterization of canine PYY

Peptides, 1990
PYY was purified from canine colonic mucosa by sequential steps of reverse phase HPLC and ion-exchange FPLC. Microsequence, amino acid and mass spectral analyses of the purified peptide and its tryptic fragments were consistent with the structure: YPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRY-amide. Canine PYY(1-36) has the identical sequence as porcine and rat
Viktor Eysselein, Harald Goebell, D Grandt   +2 more
exaly   +3 more sources

Two molecular forms of Peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1–36 and PYY 3–36

Regulatory Peptides, 1994
Two endogenous forms of PYY are abundant in man and dog, PYY 1-36 (PYY-I) and PYY 3-36 (PYY-II). PYY-II is a major molecular form of PYY in human colon, but it is not known, whether PYY-II is also released into the circulating blood. Several radioimmunoassays for measuring PYY-I in plasma have been developed, but it has not been reported, whether they ...
Christoph Beglinger, D Grandt, M Schimiczek   +2 more
exaly   +3 more sources

Structure and receptor binding of PYY analogs

Peptides, 2002
Differences in the structure of PYY and two important analogs, PYY [3-36] and [Pro34]PYY, are evaluated. Y-receptor subtype ligand binding data are used in conjunction with structural data to develop a model for receptor subtype selective agonists. For PYY it is proposed that potent binding to Y1, Y4 and Y5 receptors requires the juxtaposition of the ...
David A Keire, T E Solomon, J R Reeve
exaly   +3 more sources

PYY in the Expanding Pancreatic Epithelium

Endocrine, 2006
Gut peptide YY (PYY) plays an important role in regulating metabolism and is expressed during the ontogeny of the pancreas. However, its biological role during endocrine cell formation is not fully understood, and its role, if any, during pancreatic regeneration in the adult has not yet been explored.
Guoxun, Liu, Sandrine, Arnaud-Dabernat, Marcie R, Kritzik, Ayse G, Kayali, You-Qing, Zhang, Nora, Sarvetnick   +5 more
openaire   +2 more sources

Primary structures of PYY, [Pro³⁴]PYY, and PYY-(3–36) confer different conformations and receptor selectivity

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
We synthesized PYY-(1–36) (nonselective between Y1and Y2receptor subtype agonists), [Pro34]PYY (selective for Y1), and PYY-(3–36) (selective for Y2) to determine whether solution conformation plays a role in receptor subtype selectivity. The three peptides exhibited the expected specificities in displacing labeled PYY-(1–36) from cells transfected with
D A, Keire, P, Mannon, M, Kobayashi, J H, Walsh, T E, Solomon, J R, Reeve   +5 more
openaire   +2 more sources

Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002
The influence of intravenous peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125, and 250 pmol · kg−1 · h−1) significantly reduced gastric lesions by 36, 59, 40, and 38%, respectively.
Keishi, Kawakubo, Hong, Yang, Yvette, Taché   +2 more
openaire   +2 more sources

A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36)

Regulatory Peptides, 2008
We purified and identified the peptide YY (PYY) forms present and determined their levels from a portion of the canine ileum directly adjacent to the cecum by a new extraction method designed to prevent and evaluate degradation of endogenous peptides.
David A Keire, Julian P Whitelegge, Sara Bassilian   +2 more
exaly   +3 more sources

PP, PYY, and NPY

1993
Physiological events in peripheral organs are centrally as well as locally regulated. Central control is concerned with major functional adjustments, and is exercised mainly by parasympathetic and sympathetic nerves and by the hypothalamo-pituitary axis.
F. Sundler, G. Böttcher, E. Ekblad, R. Håkanson   +3 more
openaire   +1 more source