Results 101 to 110 of about 936,931 (309)

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Image1_Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS.pdf

Background: The Jiawei Kongsheng Zhenzhong pill (JKZP), a Chinese herbal prescription comprised of eight Chinese crude drugs, has been historically employed to treat neurological and psychological disorders.
Yue Zhao (186573), Zhichun Wu (8666085), Qiaolan Wu (17901800), Jiayun Wang (11294127), Chunxue Ou (17901803), Zu Gao (17901806), Guangying Lu (2201740), Xiaolin Wu (1682056), Huayun Yu (2689498)   +8 more
core   +1 more source

Identification of SPLs in parental and dox-resistant MCF-7 cells using UHPLC-Q-TOF.

, 2021
Identification of SPLs in parental and dox-resistant MCF-7 cells using UHPLC-Q-TOF.
Sameh S. M. Soliman (9465380), Naglaa S. Ashmawy (10792551), Sarra B. Shakartalla (9465395), Alaa M. Altaie (11553066), Ola D. A. Shammout (11553063), Mohammad H. Semreen (2134234), Hany A. Omar (7592393)   +6 more
core   +1 more source

A Novel Approach Based on Acceptor–Donor–Acceptor Type Molecules Enhances the Therapeutic Efficacy and Safety of Photothermal Therapy for Osteosarcoma

Advanced Science, EarlyView.
Jin et al. developed IEICO‐F nanoparticles with enhanced photothermal conversion efficiency via optimized push‐pull effect. Under 808 nm laser, these nanoparticles effectively generated heat to kill osteosarcoma cells and exhibited significant tumor suppression in vivo. Therefore, this novel A‐D‐A type molecule‐based photothermal therapy strategy holds
Zhijian Jin, Hongru Wang, Yi Yang, Yuhang Xie, Yuan Zhang, Zhiye Du, Yi Huang, Wei Guo, Yang Li, Shidong Wang   +9 more
wiley   +1 more source

Table1_Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation.DOCX

, 2022
Insomnia, whether chronic or intermittent, is a common central nervous system disease. Ciwujia Tablet (CWT) is a well-known traditional Chinese medicine (TCM) made from the extract of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim.
Le Yang (345935), Hui Sun (107933), Xijun Wang (413258), Hongda Liu (6702581), Guangli Yan (413257), Zhineng Li (412763), Chunlei Wan (1510855), Ying Han (137520)   +7 more
core   +1 more source

Study on the Degradation Products of Zearalenone Using UHPLC-Q-TOF-MS

Liang you shipin ke-ji
The study employed UHPLC-Q-TOF-MS to analyze zearalenone (ZEN) in maize processed by high-temperature and high-pressure extrusion. The degradation efficiency and degradation products were investigated.
REN Ling-yun, YANG Lin-lin, JIANG Yuan-yuan, DONG Bin, WANG Jun, XUE Xia, WANG Fei-fei, ZHANG Jin-na   +7 more
doaj   +1 more source

Screening Senyawa Metabolit Sekunder Pada Fungi Laut Emericella Nidulans

EduChemia, 2016
: Investigation bioactive secondary metabolite previously, Research Center for Marine and Fisheries Product Processing and Biotechnology found anticancer properties to Emericella nidulans marine fungi strain MFW39 isolated from ascidia Aplidium ...
Irah Namirah, Antonius Herry Cahyana, Muhammad Nursid, Nurrahmi Dewi Fajarningsih   +3 more
doaj   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

DataSheet1_Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation.docx

, 2022
Insomnia, whether chronic or intermittent, is a common central nervous system disease. Ciwujia Tablet (CWT) is a well-known traditional Chinese medicine (TCM) made from the extract of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim.
Le Yang (345935), Hui Sun (107933), Xijun Wang (413258), Hongda Liu (6702581), Guangli Yan (413257), Zhineng Li (412763), Chunlei Wan (1510855), Ying Han (137520)   +7 more
core   +1 more source