Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs. [PDF]
PLoS Genetics, 2013 Because cohesion prevents sister-chromatid separation and spindle elongation, cohesion dissolution may trigger these two events simultaneously. However, the relatively normal spindle elongation kinetics in yeast cohesin mutants indicates an additional ...
Fengshan Liang +2 more
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COE loss-of-function analysis reveals a genetic program underlying maintenance and regeneration of the nervous system in planarians. [PDF]
PLoS Genetics, 2014 Members of the COE family of transcription factors are required for central nervous system (CNS) development. However, the function of COE in the post-embryonic CNS remains largely unknown.
Martis W Cowles +4 more
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Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels. [PDF]
PLoS Genetics, 2014 DNA methylation is an important epigenetic regulator of gene expression. Recent studies have revealed widespread associations between genetic variation and methylation levels.
Nicholas E Banovich +8 more
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The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination. [PDF]
PLoS Genetics, 2012 Class-switch recombination (CSR), induced by activation-induced cytidine deaminase (AID), can be divided into two phases: DNA cleavage of the switch (S) regions and the joining of the cleaved ends of the different S regions.
Andre Stanlie +3 more
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Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. [PDF]
PLoS Genetics, 2012 Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing ...
He Gong +8 more
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Frontiers in Genetics, 2018 There are increasing concerns regarding the impact of agrochemical pesticides on non-target organisms. Pesticides could cause honeybee abnormal development in response to neurotoxins such as neonicotinoid.
Kang Wang +9 more
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The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. [PDF]
PLoS Genetics, 2012 Mobile group II introns are bacterial retrotransposons that are thought to have invaded early eukaryotes and evolved into introns and retroelements in higher organisms.
Travis B White, Alan M Lambowitz
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Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. [PDF]
PLoS Genetics, 2011 DNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the total DNA methylation content in human ...
Michael J Ziller +11 more
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Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
Genetics and Molecular Biology, 2011 A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation.
Lizcano Fernando +2 more
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Molecular Genetics & Genomic Medicine, 2019 Background The implementation of molecular karyotyping has resulted in an improved diagnostic yield in the genetic diagnostics of congenital anomalies, detected prenatally or after the termination of pregnancy.
Gorazd Rudolf +4 more
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