Results 81 to 90 of about 29,861 (222)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal +6 more
wiley +1 more source
Jurnal Kimia Sains dan AplikasiBreast cancer is one of the most problematic diseases in the world. Currently, there are no potential vaccines for the treatment of this disease. Therefore, finding effective compounds, such as curcumin analogs, is crucial to inhibit breast cancer. Forty-
Neni Frimayanti, Adel Zamri, Yum Eryanti
doaj +1 more source
Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva +8 more
wiley +1 more source
Deliberating the scientific evidence base for influenza transmission to raw milk consumers
Risk Analysis, Volume 45, Issue 10, Page 2939-2955, October 2025.Abstract Transmission of influenza A H5N1, commonly known as avian influenza or bird flu, from wild birds to cows on 1073 large US dairy farms in 17 states, and from cows to 41 dairy workers in five states, has raised concerns about limited evidence for transmission routes.
Margaret E. Coleman
wiley +1 more source
EFSA Journal, Volume 23, Issue 10, October 2025.Abstract The European Commission asked EFSA to provide support in the framework of Article 43 of Regulation (EC) No 396/2005 for the preparation of the EU position for 56th Session of the Codex Committee on Pesticide Residues (CCPR). In the current report, EFSA provided comments and recommendations on the Codex maximum residue limit (CXL) proposals ...
EFSA (European Food Safety Authority)
wiley +1 more source
Recommendations for CoMFA Studies and 3D QSAR Publications [PDF]
, 1994 Ulrich Thibaut +5 more
openalex +1 more source
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
Molecules, 2011 A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a–g were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pretreated with 1 μM phenylephrine (PE).
Yongzhou Hu +7 more
doaj +1 more source
QSAR: a abordagem de Hansch [PDF]
Química Nova, 2004 The Hansch Analysis, also known by QSAR-2D, is an extremely effective tool in the identification and/or improvement of the pharmacological or toxicological profile of xenobiotics. This article presents the theme didactically and with enough detail to clarify the conceptual basis of Hansch Analysis.
openaire +5 more sources