Results 261 to 270 of about 39,485 (293)
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Methods, 2007
Melting curves are commonly used to determine the stability of folded nucleic acid structures and their interaction with ligands. This paper describes how the technique can be applied to study the properties of four-stranded nucleic acid structures that are formed by G-rich oligonucleotides.
Rachwal, Phillip A., Fox, Keith R.
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Melting curves are commonly used to determine the stability of folded nucleic acid structures and their interaction with ligands. This paper describes how the technique can be applied to study the properties of four-stranded nucleic acid structures that are formed by G-rich oligonucleotides.
Rachwal, Phillip A., Fox, Keith R.
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to ...
Robert W, Harkness +1 more
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G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to ...
Robert W, Harkness +1 more
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RNA G-Quadruplexes: G-quadruplexes with “U” Turns
Current Pharmaceutical Design, 2012G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has contributed to a great deal of understanding of these unusual structures in DNA.
Tani, Agarwal +4 more
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Luminescent G-quadruplex Probes
Current Pharmaceutical Design, 2012G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature.
Yang, H +4 more
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DNA quadruplex folding formalism – A tutorial on quadruplex topologies
Methods, 2013Quadruplexes of DNA adopt a large variety of topologies that are dependent on their environment. We have been developing a formalism for quadruplex folding based on the relationship between base and its sugar--as defined by the glycosidic bond angle. By reducing the quadruplex stem to a description based on two finite states of the range of angles the ...
Andreas Ioannis Karsisiotis +2 more
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Macrocyclic G-Quadruplex Ligands
Current Medicinal Chemistry, 2010G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the ...
Nielsen, M C, Ulven, Trond
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Biochimie, 2008
Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
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Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
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Conformational Plasticity of Parallel G-Quadruplex─Implications on Duplex–Quadruplex Motifs
Journal of the American Chemical Society, 2023DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of functions enabled by their unique and diverse structures. In this study, we focus on the conformational plasticity of the most abundant and biologically relevant parallel G-quadruplex topology.
Rajesh Kumar Reddy Sannapureddi +3 more
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Higher-Order Quadruplex Structures
2012Structural studies have shown that four G-tracts along a DNA strand are the minimal requirement for intramolecular G-quadruplex formation. Longer DNA sequences containing multiples of four G-tracts could, in principle, form higher-order structures based on multiple G-quadruplex blocks.
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Human Papillomavirus G-Quadruplexes
Biochemistry, 2013Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world's most significant health problems.
Katarína Tluková +6 more
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