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The Diet-Multiple Sclerosis Connection: Oxidative Stress and Emerging Mechanisms. [PDF]
Mol NeurobiolBucciero C +8 more
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Green synthesis of silver nanoparticles using Rumex. crispus seeds and synergistic application of photodynamic/photothermal antimicrobial therapy. [PDF]
BMC BiotechnolNomani A +4 more
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Recent advances on G-quadruplex for biosensing, bioimaging and cancer therapy
TrAC - Trends in Analytical Chemistry, 2021G-quadruplex is a three-dimensional secondary structure of nucleic acids formed by the Hoogsteen hydrogen pairing of four guanines. Diverse topologies of G-quadruplex could be employed in biosensing and bioimaging. By intercalating fluorescence dyes into
Hailun He, Jiaqi Xu, Zhenwei Tang
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DNA quadruplex folding formalism – A tutorial on quadruplex topologies
Methods, 2013Quadruplexes of DNA adopt a large variety of topologies that are dependent on their environment. We have been developing a formalism for quadruplex folding based on the relationship between base and its sugar--as defined by the glycosidic bond angle. By reducing the quadruplex stem to a description based on two finite states of the range of angles the ...
Mateus Webba da Silva +2 more
exaly +3 more sources
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies.
Trends in Molecular Medicine, 2020The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively.
Josué Carvalho +4 more
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Origins of Life and Evolution of Biospheres, 2021
The RNA world hypothesis relies on the double-helix complementarity principle for both replication and catalytic activity of RNA. However, the de novo appearance of the complementarity rules, without previous evolution steps, is doubtful. Another major problem of the RNA world is its isolated nature, making it almost impossible to accommodate the ...
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The RNA world hypothesis relies on the double-helix complementarity principle for both replication and catalytic activity of RNA. However, the de novo appearance of the complementarity rules, without previous evolution steps, is doubtful. Another major problem of the RNA world is its isolated nature, making it almost impossible to accommodate the ...
openaire +2 more sources
Methods, 2007
Melting curves are commonly used to determine the stability of folded nucleic acid structures and their interaction with ligands. This paper describes how the technique can be applied to study the properties of four-stranded nucleic acid structures that are formed by G-rich oligonucleotides.
Rachwal, Phillip A., Fox, Keith R.
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Melting curves are commonly used to determine the stability of folded nucleic acid structures and their interaction with ligands. This paper describes how the technique can be applied to study the properties of four-stranded nucleic acid structures that are formed by G-rich oligonucleotides.
Rachwal, Phillip A., Fox, Keith R.
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RNA G-Quadruplexes: G-quadruplexes with “U” Turns
Current Pharmaceutical Design, 2012G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has contributed to a great deal of understanding of these unusual structures in DNA.
Tani, Agarwal +4 more
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