Results 261 to 270 of about 29,743 (315)

Hunting G-quadruplexes

Biochimie, 2008
Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
openaire   +2 more sources

Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome.

Chemical Communications, 2020
G-quadruplexes are nucleic acids secondary structures that can be formed in guanine-rich sequences. More than 30 years ago, their formation was first observed in telomeric DNA.
Federica Raguseo, Souroprobho Chowdhury, Aisling Minard, M. Di Antonio   +3 more
semanticscholar   +1 more source

Research Progress of RNA Quadruplex

Oligonucleotides, 2011
RNA/DNA sequences rich in guanine (G) can form a 4-strand structure, G-quadruplex, which has been extensively researched and observed in mammalian, fungi, and plants, with in vivo existence in eukaryotic cells. Compared with DNA quadruplex, the potential existence of RNA quadruplex appears to
Xiaohui, Ji, Hongxia, Sun, Huaxi, Zhou, Junfeng, Xiang, Yalin, Tang, Changqi, Zhao   +5 more
openaire   +3 more sources

Macrocyclic G-Quadruplex Ligands

Current Medicinal Chemistry, 2010
G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the ...
Nielsen, M C, Ulven, Trond
openaire   +3 more sources

Engineered Dynamic Boronate Esters Mediated Self-healable Biocompatible G-quadruplex Hydrogel for Sustained Release of Vitamins.

Langmuir, 2020
The injectable, self-healable and biocompatible dynamic hydrogels prepared from the molecular self-assembly and reversible covalent bond formation of low molecular weight hydrogelators are increasing in the field of drug delivery.
T. Ghosh, A. Biswas, P. K. Gavel, Apurba K. Das   +3 more
semanticscholar   +1 more source

Thermodynamics of G-quadruplexes

2012
In 1910 Ivar Bang reported that concentrated solutions of guanylic acid formed a gel. It took half a century before Gellert et al. in 1962 discovered the structural motif, a guanine-quartet, to be the basis for guanylic acid gelation. This chapter starts with a historical overview and gives credit to Ivar Bang and several other pioneers in the field ...
openaire   +2 more sources

Higher-Order Quadruplex Structures

2012
Structural studies have shown that four G-tracts along a DNA strand are the minimal requirement for intramolecular G-quadruplex formation. Longer DNA sequences containing multiples of four G-tracts could, in principle, form higher-order structures based on multiple G-quadruplex blocks.
openaire   +3 more sources

G-quadruplex DNAzyme as peroxidase mimetic in a colorimetric biosensor for ultrasensitive and selective detection of trace tetracyclines in foods.

Food Chemistry, 2021
Yue Tang, Xiaohuan Huang, Xueli Wang, Chunxiao Wang, Han Tao, Yuangen Wu   +5 more
semanticscholar   +1 more source

Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array

Nature Chemistry, 2021
Junyi Chen, Briana L Hickey, Linlin Wang, Jiwon Lee, Adam D. Gill, Alessia Favero, R. Pinalli, E. Dalcanale, R. Hooley, Wenwan Zhong   +9 more
semanticscholar   +1 more source

G-quadruplex structures mark human regulatory chromatin

Nature Genetics, 2016
Robert Hänsel-Hertsch, D. Beraldi, Stefanie V. Lensing, Giovanni Marsico, Katherine G. Zyner, Aled J. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian   +11 more
semanticscholar   +1 more source