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Quadruplex World

Origins of Life and Evolution of Biospheres, 2021
The RNA world hypothesis relies on the double-helix complementarity principle for both replication and catalytic activity of RNA. However, the de novo appearance of the complementarity rules, without previous evolution steps, is doubtful. Another major problem of the RNA world is its isolated nature, making it almost impossible to accommodate the ...
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Quadruplex melting

Methods, 2007
Melting curves are commonly used to determine the stability of folded nucleic acid structures and their interaction with ligands. This paper describes how the technique can be applied to study the properties of four-stranded nucleic acid structures that are formed by G-rich oligonucleotides.
Rachwal, Phillip A., Fox, Keith R.
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DNA quadruplex folding formalism – A tutorial on quadruplex topologies

Methods, 2013
Quadruplexes of DNA adopt a large variety of topologies that are dependent on their environment. We have been developing a formalism for quadruplex folding based on the relationship between base and its sugar--as defined by the glycosidic bond angle. By reducing the quadruplex stem to a description based on two finite states of the range of angles the ...
Andreas Ioannis Karsisiotis   +2 more
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