Results 251 to 260 of about 29,743 (315)

A Sensitive Aptasensor Based on a Hemin/G-Quadruplex-Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes.

Small, 2019
Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of the tumor microenvironment. However, it remains a major problem to detect cancer-specific exosomes due to technical
Rongrong Huang, Lei He, Yanyan Xia, Hongpan Xu, Chang Liu, Hui Xie, Su Wang, Lijun Peng, Yufeng Liu, Yuan Liu, N. He, Zhiyang Li   +11 more
semanticscholar   +1 more source

G-Quadruplex-Induced Liquid-Liquid Phase Separation in Biomimetic Protocells.

Journal of the American Chemical Society, 2021
Biomolecular condensates comprised of specific proteins and nucleic acids are now recognized as one of the key organizing mechanisms in eukaryotic cells.
Xuejiao Liu, Yansong Xiong, Chunjuan Zhang, Rongji Lai, Hui Liu, Ruizi Peng, Ting Fu, Qiaoling Liu, X. Fang, S. Mann, W. Tan   +10 more
semanticscholar   +1 more source

G-quadruplex dynamics

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to ...
Robert W, Harkness, Anthony K, Mittermaier   +1 more
openaire   +2 more sources

Amplified Electrochemical Hydrogen Peroxide Sensing Based on Cu-porphyrin Metal Organic Framework Nanofilm and G-quadruplex-hemin DNAzyme.

ACS Applied Materials and Interfaces, 2020
A novel electrochemical hydrogen peroxide (H2O2) sensor based on Cu-porphyrin(Cu-TCPP)/G-quadruplex-hemin nanocomposite was constructed by assembling two-dimensional Cu-TCPP metal organic framework nanofilm and G-quadruplex-hemin DNAzyme.
Junping Ma, Guozhen Chen, Wushuang Bai, Jianbin Zheng   +3 more
semanticscholar   +1 more source

A PNA₄ Quadruplex

Journal of the American Chemical Society, 2004
A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers
Yamuna, Krishnan-Ghosh, Elaine, Stephens, Shankar, Balasubramanian   +2 more
openaire   +2 more sources

G-quadruplex DNA for construction of biosensors

, 2020
DNA-based biosensors have been widely used for its stable chemical properties, cost-effectiveness, and easy modification. G-quadruplex (G4) DNA has attracted growing interest since it can be used for both target recognition and signal transduction.
Hualin Yang, Yu Zhou, Juewen Liu
semanticscholar   +1 more source

STRUCTURAL STUDIES ON LNA QUADRUPLEXES

Nucleosides, Nucleotides & Nucleic Acids, 2005
LNAs (locked nucleic acids) are new DNA analogues with higher binding affinities toward nucleic acids than the canonical counterparts mainly due to the characteristic conformational restriction arising from the 2'-O, 4'-C methylene bridge. In light of the promising therapeutic applications and considering the advantageous characteristics of LNAs, such ...
RANDAZZO, ANTONIO, ESPOSITO, VERONICA, OLIVER OHLENSCHLÄGER, RAMADURAI RAMACHANDRAN, VIRGILIO, ANTONELLA, MAYOL, LUCIANO   +5 more
openaire   +3 more sources

Luminescent G-quadruplex Probes

Current Pharmaceutical Design, 2012
G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature.
Yang, H, Chan, DSH, Ma, DL, Leung, CH, He, HZ   +4 more
openaire   +4 more sources

Molecular Modeling and Simulation of G-Quadruplexes and Quadruplex-Ligand Complexes

2009
Methods for the molecular modeling and simulation of G-quadruplex structures and their drug/ligand complexes are discussed, and a range of protocols is presented for undertaking a variety of tasks including model-building, ligand docking, dynamics simulation, continuum solvent modeling, energetic calculations, principal component analysis, and quantum ...
Haider, Shozeb, Neidle, S.
openaire   +3 more sources

Content Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structures.

Angewandte Chemie, 2020
G-quadruplex DNA undergoes structural polymorphism, leading challenging around using selectively recognizing probe to accurately detect G-quadruplexes in vivo .
Liu‐Yi Liu, Wenting Liu, Kang‐Nan Wang, Bo‐Chen Zhu, Xiao‐Yu Xia, L. Ji, Z. Mao   +6 more
semanticscholar   +1 more source