Results 41 to 50 of about 39,485 (293)

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure. [PDF]

, 2016
Recognition of the fundamental importance of allosteric regulation in biology dates back to not long after its discovery in the 1960s. Our ability to rationally engineer this potentially useful property into normally non-allosteric catalysts, however ...
Fan, Chunhai, Huang, Qing, Li, Jiang, Mao, Xiuhai, Pei, Hao, Plaxco, Kevin W, Shi, Jiye, Simon, Anna J   +7 more
core   +1 more source

The Targeting of Quadruplex Nucleic Acids in Human Cancers

Proceedings, 2019
The overwhelming majority of DNA in the human genome is double-stranded. However,regions comprising several short guanine-tracts are capable of forming higher-order structures,termed quadruplexes. [...]
Stephen Neidle
doaj   +1 more source

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
core   +1 more source

Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability

Microorganisms, 2020
G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh, Frank Wien, Wilfried Grange, Thomas A. De Long, Véronique Arluison, Richard R. Sinden   +5 more
doaj   +1 more source

PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells [PDF]

, 2016
G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability.
Bailey, Laura J, Doherty, Aidan J, Guilbaud, Guillaume, Guilliam, Thomas A, Jozwiakowski, Stanislaw K, Romanello, Marina, Sale, Julian E, Schiavone, Davide   +7 more
core   +1 more source

G-quadruplex organic frameworks [PDF]

Nature Chemistry, 2016
Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu, Noah E. Horwitz, Kan-Sheng Chen, Diego A. Gomez-Gualdron, Norman S. Luu, Lin Ma, Timothy C. Wang, Mark C. Hersam, Joseph T. Hupp, Omar K. Farha, Randall Q. Snurr, Michael R. Wasielewski   +11 more
openaire   +3 more sources

G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome. [PDF]

PLoS ONE, 2016
The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the ...
Andrzej S Kudlicki
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Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays. [PDF]

, 2015
A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs).
Bazan, Guillermo C, Hwang, Sungu, Jeong, Ji-Eun, Kim, Boram, Woo, Han Young, Woo, Shinjae   +5 more
core   +1 more source

G-quadruplexes and helicases [PDF]

Nucleic Acids Research, 2016
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar, Bourdoncle, Anne, Boulé, Jean-Baptiste, Brosh, Robert, Mergny, Jean-Louis   +4 more
openaire   +3 more sources

The quadruplex TaqMan MGB fluorescent quantitative PCR method for simultaneous detection of feline panleukopenia virus, feline herpesvirus 1, feline calicivirus and feline infectious peritonitis virus

Frontiers in Cellular and Infection Microbiology
BackgroundFeline panleukopenia, feline calicivirus infection, feline viral rhinotracheitis, and feline infectious peritonitis are significant diseases that threaten feline health.
Haojie Wang, Lihong Xue, Longxi Wang, Yixuan Liu, Jianxing Chen, Yue Sun, Tongqing An, Hongyan Chen, Changqing Yu, Changyou Xia, He Zhang   +10 more
doaj   +1 more source