Results 111 to 120 of about 6,574,159 (309)

Early School Leaving by Design—Prevention, Intervention and Compensation—A Policy Analysis of Early School Leaving and Underachievement Interventions in Europe

Education Sciences
The purpose of this paper is to provide a comparative policy analysis of successful strategies that have been implemented across European countries to address early school leaving (ESL) and academic underachievement.
Martin Brown, Joe O’Hara, Sarah Gardezi, Gerry McNamara, John O’Hara, Geraldine French, Grainne McKenna, Aideen Cassidy, Anne Rowan, Michael McNamara   +9 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Promoting the process of determining brain death through standardized training

Frontiers in Neurology
ObjectiveThis study aims to explore the training mode for brain death determination to ensure the quality of subsequent brain death determination.MethodsA four-skill and four-step (FFT) training model was adopted, which included a clinical neurological ...
Yingying Su, Yingying Su, Yan Zhang, Yan Zhang, Hong Ye, Hong Ye, Weibi Chen, Weibi Chen, Linlin Fan, Linlin Fan, Gang Liu, Gang Liu, Huijin Huang, Huijin Huang, Daiquan Gao, Daiquan Gao, Yunzhou Zhang, Yunzhou Zhang   +17 more
doaj   +1 more source

Data-driven Natural Language Generation: Paving the Road to Success

, 2017
We argue that there are currently two major bottlenecks to the commercial use of statistical machine learning approaches for natural language generation (NLG): (a) The lack of reliable automatic evaluation metrics for NLG, and (b) The scarcity of high ...
Dušek, Ondřej, Novikova, Jekaterina, Rieser, Verena   +2 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Staging lung cancer: total-body PET/CT or whole-body PET/CT?

EJNMMI Research
Background Total Body PET/CT is increasingly used in clinical practice, but its benefits for lung cancer staging are not fully established. This study aimed to evaluate the impact of Total Body PET/CT on lung cancer staging compared to traditional Whole ...
Xiaoxiang Zhang, Jiahao Xie, Yuzhao Zheng, Ying Tian, Xiaohui Chen, Li Chen, Kemin Zhou, Penghui Sun, Wenlan Zhou, Hubing Wu   +9 more
doaj   +1 more source

Quality of information and the goals and targets of the organization: A model and method [PDF]

In this paper a framework is presented for the ex-post evaluation of the quality of information in organizations. The framework brings together several approaches to quality that can be found in the literature, which however, offers no approach to the ...
Pijl, G.J. van der
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Integrative analyses of the transcriptome and metabolome reveal comprehensive mechanisms of monolignol biosynthesis in response to bioclimatic factors in Magnolia officinalis

BMC Plant Biology
Background Magnolia officinalis (M. officinalis) thrives in temperate, elevated regions, and its desiccated bark comprises medicinal monolignol. Both abiotic and biotic factors can influence the pharmacodynamic compounds of M.
Mingxin Zhong, Qian Wang, Hui Tian, Bainian Zhang, Zhuo Xu, Yuanyuan Zhang, Chengjia Tan, Xin Hu, Tao Wang, Daren Feng, Zhenpeng Xi   +10 more
doaj   +1 more source

Proteomics and Its Combined Analysis with Transcriptomics: Liver Fat-Lowering Effect of Taurine in High-Fat Fed Grouper (Epinephelus coioides)

Animals
In order to understand the intervention effect of taurine on liver fat deposition induced by high fat intake in the orange-spotted grouper (Epinephelus coioides), we performed proteomic analysis and association analysis with previously obtained ...
Yu Zhou, Fakai Bai, Ruyi Xiao, Mingfan Chen, Yunzhang Sun, Jidan Ye   +5 more
doaj   +1 more source