Results 121 to 130 of about 2,456,901 (316)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A controlled vocabulary and taxonomy for the submission of quality attributes for therapeutic proteins

AAPS Open
Structured product quality data offer tremendous promise to revolutionize the submission of drug applications. However, the quality attributes for biological products do not have a systematic naming taxonomy, and consequently this limit poses a critical ...
Joel T. Welch, Steven Kozlowski, Bazarragchaa Damdinsuren, Brian A. Roelofs   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections

AAPS Open
Freeze-drying has been a workhorse for the pharmaceutical industry to enable long-term storage and long-distance transport of drug products that are unstable in liquid or frozen form.
Steve Y. Rhieu, Maxwell Korang-Yeboah, David D. Anderson, John Arigo, Thomas O’Connor, Rakhi Shah   +5 more
doaj   +1 more source

Effects of Varying Dietary Lipid and Starch Levels on Growth Performance, Biochemical Components, and Hepatic Glycolipid Metabolism in Hybrid Grouper (Epinephelus lanceolatus ♂ × E. fuscoguttatus ♀)

Animals
A 56-day feeding trial was conducted to evaluate the effects of varying dietary lipid and starch levels on growth performance, biochemical components, and hepatic glycolipid metabolism in hybrid grouper.
Songhang Li, Kun Wang, Mengyao Chen, Yuan Li, Chong Wang, Kai Song, Yichuang Xu, Jidan Ye   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

ClusterEval 1.0 : Cluster quality Evaluation software

, 2013
This report describes the available functionality and use of the ClusterEval evaluation software. It implements novel and standard measures for the evaluation of cluster quality.
De Vries, Christopher M., Geva, Shlomo
core  

Development and preliminary evaluation of a Filter Quality Testing System

Cleaner Engineering and Technology
Reliable evaluation of air filtration materials remains challenging due to the lack of standardized, affordable, and versatile testing systems that can simulate real-world environmental conditions.
Kirti Jalgaonkar, P. Jagajanantha, Manoj Kumar Mahawar, A.S.M. Raja   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source