Results 121 to 130 of about 6,659,971 (307)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Report on objective ride quality evaluation [PDF]

The correlation of absorbed power as an objective ride measure to the subjective evaluation for the bus data was investigated. For some individual bus rides the correlations were poor, but when a sufficient number of rides was used to give reasonable ...
Park, W. H., Wambold, J. C.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Early School Leaving by Design—Prevention, Intervention and Compensation—A Policy Analysis of Early School Leaving and Underachievement Interventions in Europe

Education Sciences
The purpose of this paper is to provide a comparative policy analysis of successful strategies that have been implemented across European countries to address early school leaving (ESL) and academic underachievement.
Martin Brown, Joe O’Hara, Sarah Gardezi, Gerry McNamara, John O’Hara, Geraldine French, Grainne McKenna, Aideen Cassidy, Anne Rowan, Michael McNamara   +9 more
doaj   +1 more source

Evaluation of Quality of Life Using Short Form-36 and Visual Analogue Scale After Posterior Instrumentation and Fusion in Tuberculous Spondylitis Patients at Cipto Mangunkusumo Hospital [PDF]

, 2012
Introduction.Tuberculous spondylitis is a devastating health problem in Indonesia. The goal of treatment is to relieve pain, so the patients can do their daily activities.
Silas, C. (Christian), Tobing, S. D. (Singkat)   +1 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Promoting the process of determining brain death through standardized training

Frontiers in Neurology
ObjectiveThis study aims to explore the training mode for brain death determination to ensure the quality of subsequent brain death determination.MethodsA four-skill and four-step (FFT) training model was adopted, which included a clinical neurological ...
Yingying Su, Yingying Su, Yan Zhang, Yan Zhang, Hong Ye, Hong Ye, Weibi Chen, Weibi Chen, Linlin Fan, Linlin Fan, Gang Liu, Gang Liu, Huijin Huang, Huijin Huang, Daiquan Gao, Daiquan Gao, Yunzhou Zhang, Yunzhou Zhang   +17 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Staging lung cancer: total-body PET/CT or whole-body PET/CT?

EJNMMI Research
Background Total Body PET/CT is increasingly used in clinical practice, but its benefits for lung cancer staging are not fully established. This study aimed to evaluate the impact of Total Body PET/CT on lung cancer staging compared to traditional Whole ...
Xiaoxiang Zhang, Jiahao Xie, Yuzhao Zheng, Ying Tian, Xiaohui Chen, Li Chen, Kemin Zhou, Penghui Sun, Wenlan Zhou, Hubing Wu   +9 more
doaj   +1 more source