Results 111 to 120 of about 13,878,475 (299)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Second-generation lectin microarray for high throughput glycan profiling of therapeutic antibodies

AAPS Open
N-linked glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs), influencing efficacy, safety, and pharmacokinetics.
Kayla Hess, Helena Yun, Shen Luo, Uriel Ortega-Rodriguez, Grace Henry Lunde, Sarah Rogstad, Lai-Xi Wang, Baolin Zhang   +7 more
doaj   +1 more source

Effects of Varying Dietary Lipid and Starch Levels on Growth Performance, Biochemical Components, and Hepatic Glycolipid Metabolism in Hybrid Grouper (Epinephelus lanceolatus ♂ × E. fuscoguttatus ♀)

Animals
A 56-day feeding trial was conducted to evaluate the effects of varying dietary lipid and starch levels on growth performance, biochemical components, and hepatic glycolipid metabolism in hybrid grouper.
Songhang Li, Kun Wang, Mengyao Chen, Yuan Li, Chong Wang, Kai Song, Yichuang Xu, Jidan Ye   +7 more
doaj   +1 more source

Quality Educational Services in University: Self-Evaluation Using Quality Indicators [PDF]

This paper seeks to help us answer following aspects: The University could be able to offer good educational services? Are these services at higher standards?
Corina CACE
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology
Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases.
Haifan Liu, Xingyue Jin, Suyi Liu, Xinyue Liu, Xiao Pei, Kunhui Sun, Meifang Li, Ping Wang, Yanxu Chang, Tiejie Wang, Bing Wang, Xie-an Yu   +11 more
doaj   +1 more source

NMR-based structural integrity analysis of therapeutic monoclonal antibodies: a comparative study of Humira and its biosimilars

mAbs
The analytical comparability of biologic products and their biosimilars, including higher-order structure (HOS) assessment, ensures product quality and is required for regulatory approval.
Donna Baldisseri, Shen Luo, Christelle Anne F. Ancajas, Uriel Ortega-Rodriguez, Christian Fischer, Guozhang Zou, Jianghong Gu, David Keire, Martial Piotto, Baolin Zhang   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections

AAPS Open
Freeze-drying has been a workhorse for the pharmaceutical industry to enable long-term storage and long-distance transport of drug products that are unstable in liquid or frozen form.
Steve Y. Rhieu, Maxwell Korang-Yeboah, David D. Anderson, John Arigo, Thomas O’Connor, Rakhi Shah   +5 more
doaj   +1 more source

Carbamazepine activates private self and viral reactive TCRs through a drug-permissive HLA-B cleft

Frontiers in Immunology
IntroductionCarbamazepine (CBZ) can cause severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis, and is strongly associated with HLA risk alleles. However, HLA genotype alone incompletely predicts clinical risk.
SuJin Hwang, Masahide Yano, Yura Jang, Maryam Khalaj, Elliot Mattson, Li Lu, Stephanie Kortchak, Jason Gorman, Montserrat Puig, Michael Norcross   +9 more
doaj   +1 more source